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Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).
Frauenstein K, Tigges J, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CF, Haarmann-Stemmann T. Frauenstein K, et al. Among authors: haendeler j. Arch Toxicol. 2015 Aug;89(8):1329-36. doi: 10.1007/s00204-014-1321-8. Epub 2014 Aug 1. Arch Toxicol. 2015. PMID: 25082669 Free PMC article.
The hallmarks of fibroblast ageing.
Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F. Tigges J, et al. Among authors: haendeler j. Mech Ageing Dev. 2014 Jun;138:26-44. doi: 10.1016/j.mad.2014.03.004. Epub 2014 Mar 29. Mech Ageing Dev. 2014. PMID: 24686308 Review.
The aryl hydrocarbon receptor promotes aging phenotypes across species.
Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J. Eckers A, et al. Among authors: haendeler j. Sci Rep. 2016 Jan 21;6:19618. doi: 10.1038/srep19618. Sci Rep. 2016. PMID: 26790370 Free PMC article.
MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4.
Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP. Lang A, et al. Among authors: haendeler j. Aging (Albany NY). 2016 Mar;8(3):484-505. doi: 10.18632/aging.100905. Aging (Albany NY). 2016. PMID: 26959556 Free PMC article.
Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation.
Peuschel H, Sydlik U, Grether-Beck S, Felsner I, Stöckmann D, Jakob S, Kroker M, Haendeler J, Gotić M, Bieschke C, Krutmann J, Unfried K. Peuschel H, et al. Among authors: haendeler j. Part Fibre Toxicol. 2012 Dec 10;9:48. doi: 10.1186/1743-8977-9-48. Part Fibre Toxicol. 2012. PMID: 23228165 Free PMC article.
141 results