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New investigations into the genotoxicity of cobalt compounds and their impact on overall assessment of genotoxic risk.
Kirkland D, Brock T, Haddouk H, Hargeaves V, Lloyd M, Mc Garry S, Proudlock R, Sarlang S, Sewald K, Sire G, Sokolowski A, Ziemann C. Kirkland D, et al. Among authors: haddouk h. Regul Toxicol Pharmacol. 2015 Oct;73(1):311-38. doi: 10.1016/j.yrtph.2015.07.016. Epub 2015 Jul 22. Regul Toxicol Pharmacol. 2015. PMID: 26210821 Free article. Review.
ADX71943 and ADX71441, novel positive allosteric modulators of the GABAB receptor with distinct central/peripheral profiles, show efficacy in the monosodium iodoacetate model of chronic osteoarthritis pain in the rat.
Kalinichev M, Donovan-Rodriguez T, Girard F, Haddouk H, Royer-Urios I, Schneider M, Bate ST, Marker C, Pomonis JD, Poli S. Kalinichev M, et al. Among authors: haddouk h. Eur J Pharmacol. 2017 Jan 15;795:43-49. doi: 10.1016/j.ejphar.2016.11.056. Epub 2016 Dec 1. Eur J Pharmacol. 2017. PMID: 27916555
Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile.
Kalinichev M, Donovan-Rodriguez T, Girard F, Riguet E, Rouillier M, Bournique B, Haddouk H, Mutel V, Poli S. Kalinichev M, et al. Among authors: haddouk h. Br J Pharmacol. 2014 Nov;171(21):4941-54. doi: 10.1111/bph.12812. Epub 2014 Sep 5. Br J Pharmacol. 2014. PMID: 24923436 Free PMC article.
The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity.
Kalinichev M, Girard F, Haddouk H, Rouillier M, Riguet E, Royer-Urios I, Mutel V, Lütjens R, Poli S. Kalinichev M, et al. Among authors: haddouk h. Neuropharmacology. 2017 Mar 1;114:34-47. doi: 10.1016/j.neuropharm.2016.11.016. Epub 2016 Nov 23. Neuropharmacology. 2017. PMID: 27889489