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A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates.
Phung I, Rodrigues KA, Marina-Zárate E, Maiorino L, Pahar B, Lee WH, Melo M, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Lopez PG, Torres JL, Ozorowski G, Eskandarzadeh S, Kubitz M, Georgeson E, Groschel B, Nedellec R, Bick M, Kaczmarek Michaels K, Gao H, Shen X, Carnathan DG, Silvestri G, Montefiori DC, Ward AB, Hangartner L, Veazey RS, Burton DR, Schief WR, Irvine DJ, Crotty S. Phung I, et al. Nat Commun. 2023 Nov 4;14(1):7107. doi: 10.1038/s41467-023-42923-x. Nat Commun. 2023. PMID: 37925510 Free PMC article.
Long-primed germinal centres with enduring affinity maturation and clonal migration.
Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torres JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S. Lee JH, et al. Nature. 2022 Sep;609(7929):998-1004. doi: 10.1038/s41586-022-05216-9. Epub 2022 Sep 21. Nature. 2022. PMID: 36131022 Free PMC article.