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Responses to the Tepotinib in Gastric Cancers with MET Amplification or MET Exon 14 Skipping Mutations and High Expression of Both PD-L1 and CD44.
Sohn SH, Sul HJ, Kim BJ, Zang DY. Sohn SH, et al. Cancers (Basel). 2022 Jul 15;14(14):3444. doi: 10.3390/cancers14143444. Cancers (Basel). 2022. PMID: 35884507 Free PMC article.
Both MET exon 14 skipping mutation (METex14SM) and high copy-number variation (CNV) lead to enhanced carcinogenesis; additionally, programmed-death ligand 1 (PD-L1) is often upregulated in cancers. In this study, we characterized the expression of MET (including METex14SM) …
Both MET exon 14 skipping mutation (METex14SM) and high copy-number variation (CNV) lead to enhanced carcinogenesis; additionally, progra …
Entrectinib Induces Apoptosis and Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer with NTRK Overexpression.
Sohn SH, Sul HJ, Kim BJ, Kim HS, Zang DY. Sohn SH, et al. Int J Mol Sci. 2021 Dec 30;23(1):395. doi: 10.3390/ijms23010395. Int J Mol Sci. 2021. PMID: 35008821 Free PMC article.
Tropomyosin receptor kinase (TRK) and receptor tyrosine kinase (RTK class VII) expression are important in many human diseases, especially cancers, including colorectal, lung, and gastric cancer. Using RNA sequencing analysis, we evaluated the mRNA expression and mutation …
Tropomyosin receptor kinase (TRK) and receptor tyrosine kinase (RTK class VII) expression are important in many human diseases, especially c …
INC280 inhibits Wnt/beta-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification.
Sohn SH, Kim B, Sul HJ, Kim YJ, Kim HS, Kim H, Seo JB, Koh Y, Zang DY. Sohn SH, et al. BMC Res Notes. 2019 Mar 11;12(1):125. doi: 10.1186/s13104-019-4163-x. BMC Res Notes. 2019. PMID: 30871613 Free PMC article.
OBJECTIVE: Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. ...In addition, c-MET …
OBJECTIVE: Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patien …