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Novel substituted 9-norbornylpurines and their activities against RNA viruses.
Sála M, Hřebabecký H, Leyssen P, Dejmek M, Dračínský M, De Palma AM, Neyts J, Nencka R. Sála M, et al. Among authors: hrebabecky h. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1963-8. doi: 10.1016/j.bmcl.2012.01.040. Epub 2012 Jan 25. Bioorg Med Chem Lett. 2012. PMID: 22310228
Nucleoside inhibitors of tick-borne encephalitis virus.
Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, Salát J, Černý J, Palus M, De Clercq E, Růžek D. Eyer L, et al. Among authors: hrebabecky h. Antimicrob Agents Chemother. 2015 Sep;59(9):5483-93. doi: 10.1128/AAC.00807-15. Epub 2015 Jun 29. Antimicrob Agents Chemother. 2015. PMID: 26124166 Free PMC article.
The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Klima M, Baumlova A, Chalupska D, Hřebabecký H, Dejmek M, Nencka R, Boura E. Klima M, et al. Among authors: hrebabecky h. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1555-63. doi: 10.1107/S1399004715009505. Epub 2015 Jun 30. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26143926
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Mejdrová I, Chalupská D, Plačková P, Müller C, Šála M, Klíma M, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Strunin D, Weber J, Lee G, Matoušová M, Mertlíková-Kaiserová H, Ziebuhr J, Birkus G, Boura E, Nencka R. Mejdrová I, et al. Among authors: hrebabecky h. J Med Chem. 2017 Jan 12;60(1):100-118. doi: 10.1021/acs.jmedchem.6b01465. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 28004945
Could 5'-N and S ProTide analogues work as prodrugs of antiviral agents?
Procházková E, Hřebabecký H, Dejmek M, Šála M, Šmídková M, Tloušťová E, Zborníková E, Eyer L, Růžek D, Nencka R. Procházková E, et al. Among authors: hrebabecky h. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126897. doi: 10.1016/j.bmcl.2019.126897. Epub 2019 Dec 17. Bioorg Med Chem Lett. 2020. PMID: 31882298
SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Sála M, De Palma AM, Hřebabecký H, Dejmek M, Dračínský M, Leyssen P, Neyts J, Mertlíková-Kaiserová H, Nencka R. Sála M, et al. Among authors: hrebabecky h. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4271-5. doi: 10.1016/j.bmcl.2011.05.070. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21684160
Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position.
Dejmek M, Sála M, Plačková P, Hřebabecký H, Mascarell Borredà L, Neyts J, Dračínský M, Procházková E, Jansa P, Leyssen P, Mertlíková-Kaiserová H, Nencka R. Dejmek M, et al. Among authors: hrebabecky h. Arch Pharm (Weinheim). 2014 Jul;347(7):478-85. doi: 10.1002/ardp.201300431. Epub 2014 Mar 20. Arch Pharm (Weinheim). 2014. PMID: 24652670
33 results