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Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.
Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1.
Sci Rep. 2019.
PMID: 30926830
Free PMC article.
Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.
Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H.
Götz A, et al. Among authors: hogel p.
Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3.
Biophys J. 2019.
PMID: 31130234
Free PMC article.
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Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.
Högel P, Götz A, Kuhne F, Ebert M, Stelzer W, Rand KD, Scharnagl C, Langosch D.
Högel P, et al.
Biochemistry. 2018 Feb 27;57(8):1326-1337. doi: 10.1021/acs.biochem.7b01197. Epub 2018 Feb 9.
Biochemistry. 2018.
PMID: 29389107
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Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase.
Werner NT, Högel P, Güner G, Stelzer W, Wozny M, Aßfalg M, Lichtenthaler SF, Steiner H, Langosch D.
Werner NT, et al. Among authors: hogel p.
Commun Biol. 2023 Feb 15;6(1):177. doi: 10.1038/s42003-023-04470-5.
Commun Biol. 2023.
PMID: 36792683
Free PMC article.
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