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Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia.
Consonni M, Garavaglia C, Grilli A, de Lalla C, Mancino A, Mori L, De Libero G, Montagna D, Casucci M, Serafini M, Bonini C, Häussinger D, Ciceri F, Bernardi M, Mastaglio S, Bicciato S, Dellabona P, Casorati G. Consonni M, et al. Among authors: haussinger d. Nat Commun. 2021 Aug 11;12(1):4844. doi: 10.1038/s41467-021-25223-0. Nat Commun. 2021. PMID: 34381053 Free PMC article.
A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.
Lepore M, de Lalla C, Gundimeda SR, Gsellinger H, Consonni M, Garavaglia C, Sansano S, Piccolo F, Scelfo A, Häussinger D, Montagna D, Locatelli F, Bonini C, Bondanza A, Forcina A, Li Z, Ni G, Ciceri F, Jenö P, Xia C, Mori L, Dellabona P, Casorati G, De Libero G. Lepore M, et al. Among authors: haussinger d. J Exp Med. 2014 Jun 30;211(7):1363-77. doi: 10.1084/jem.20140410. Epub 2014 Jun 16. J Exp Med. 2014. PMID: 24935257 Free PMC article. Clinical Trial.
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells.
Vacchini A, Chancellor A, Yang Q, Colombo R, Spagnuolo J, Berloffa G, Joss D, Øyås O, Lecchi C, De Simone G, Beshirova A, Nosi V, Loureiro JP, Morabito A, De Gregorio C, Pfeffer M, Schaefer V, Prota G, Zippelius A, Stelling J, Häussinger D, Brunelli L, Villalta P, Lepore M, Davoli E, Balbo S, Mori L, De Libero G. Vacchini A, et al. Among authors: haussinger d. Sci Immunol. 2024 May 10;9(95):eadn0126. doi: 10.1126/sciimmunol.adn0126. Epub 2024 May 10. Sci Immunol. 2024. PMID: 38728413
Catalyst control over pentavalent stereocentres.
Budeev A, Dong J, Häussinger D, Sparr C. Budeev A, et al. Among authors: haussinger d. Nat Commun. 2023 Dec 4;14(1):8013. doi: 10.1038/s41467-023-43750-w. Nat Commun. 2023. PMID: 38049395 Free PMC article.
1,107 results