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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.
Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. Srikanth S, et al. Among authors: gwack y. Nat Immunol. 2019 Feb;20(2):152-162. doi: 10.1038/s41590-018-0287-8. Epub 2019 Jan 14. Nat Immunol. 2019. PMID: 30643259 Free PMC article.
Orai1 is an essential pore subunit of the CRAC channel.
Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Prakriya M, et al. Among authors: gwack y. Nature. 2006 Sep 14;443(7108):230-3. doi: 10.1038/nature05122. Epub 2006 Aug 20. Nature. 2006. PMID: 16921383
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.
Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Ambudkar IS. Ong HL, et al. Among authors: gwack y. J Biol Chem. 2007 Mar 23;282(12):9105-16. doi: 10.1074/jbc.M608942200. Epub 2007 Jan 15. J Biol Chem. 2007. PMID: 17224452 Free PMC article.
Biochemical and functional characterization of Orai proteins.
Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Gwack Y, et al. J Biol Chem. 2007 Jun 1;282(22):16232-43. doi: 10.1074/jbc.M609630200. Epub 2007 Feb 9. J Biol Chem. 2007. PMID: 17293345 Free article.
81 results