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Page 1
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.
Giovannucci TA, Salomons FA, Haraldsson M, Elfman LHM, Wickström M, Young P, Lundbäck T, Eirich J, Altun M, Jafari R, Gustavsson AL, Johnsen JI, Dantuma NP. Giovannucci TA, et al. Among authors: gustavsson al. Cell Death Dis. 2021 Oct 6;12(10):914. doi: 10.1038/s41419-021-04191-9. Cell Death Dis. 2021. PMID: 34615851 Free PMC article.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T. Gad H, et al. Among authors: gustavsson al. Nature. 2014 Apr 10;508(7495):215-21. doi: 10.1038/nature13181. Epub 2014 Apr 2. Nature. 2014. PMID: 24695224
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner K, Maric S, Reshma RS, Almqvist H, Seashore-Ludlow B, Gustavsson AL, Poyraz Ö, Yogeeswari P, Lundbäck T, Vallin M, Sriram D, Schnell R, Schneider G. Brunner K, et al. Among authors: gustavsson al. J Med Chem. 2016 Jul 28;59(14):6848-59. doi: 10.1021/acs.jmedchem.6b00674. Epub 2016 Jul 13. J Med Chem. 2016. PMID: 27379713 Free article.
Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.
Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, Dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra JM, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M. Niklasson M, et al. Among authors: gustavsson al. Cancer Res. 2017 Apr 1;77(7):1741-1752. doi: 10.1158/0008-5472.CAN-16-2274. Epub 2017 Jan 13. Cancer Res. 2017. PMID: 28087597
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Hagenkort A, Paulin CBJ, Desroses M, Sarno A, Wiita E, Mortusewicz O, Koolmeister T, Loseva O, Jemth AS, Almlöf I, Homan E, Lundbäck T, Gustavsson AL, Scobie M, Helleday T. Hagenkort A, et al. Among authors: gustavsson al. Oncotarget. 2017 Apr 4;8(14):23713-23726. doi: 10.18632/oncotarget.15785. Oncotarget. 2017. PMID: 28423595 Free PMC article.
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T. Page BDG, et al. Among authors: gustavsson al. Nat Commun. 2018 Jan 17;9(1):250. doi: 10.1038/s41467-017-02293-7. Nat Commun. 2018. PMID: 29343827 Free PMC article.
29 results