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Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.
J Ethnopharmacol. 2024 Aug 10;330:118217. doi: 10.1016/j.jep.2024.118217. Epub 2024 Apr 17.
J Ethnopharmacol. 2024.
PMID: 38641072
Catalpolaglycone disrupts mitochondrial thermogenesis by specifically binding to a conserved lysine residue of UCP2 on the proton leak tunnel.
Shen F, Yang W, Luan G, Peng J, Li Z, Gao J, Hou Y, Bai G.
Shen F, et al. Among authors: luan g.
Phytomedicine. 2024 Mar;125:155356. doi: 10.1016/j.phymed.2024.155356. Epub 2024 Jan 14.
Phytomedicine. 2024.
PMID: 38241920
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