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Platelet MHC class I mediates CD8+ T-cell suppression during sepsis.
Guo L, Shen S, Rowley JW, Tolley ND, Jia W, Manne BK, McComas KN, Bolingbroke B, Kosaka Y, Krauel K, Denorme F, Jacob SP, Eustes AS, Campbell RA, Middleton EA, He X, Brown SM, Morrell CN, Weyrich AS, Rondina MT. Guo L, et al. Blood. 2021 Aug 5;138(5):401-416. doi: 10.1182/blood.2020008958. Blood. 2021. PMID: 33895821 Free PMC article.
Sepsis alters the transcriptional and translational landscape of human and murine platelets.
Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT. Middleton EA, et al. Among authors: guo l. Blood. 2019 Sep 19;134(12):911-923. doi: 10.1182/blood.2019000067. Epub 2019 Jul 31. Blood. 2019. PMID: 31366617 Free PMC article.
Platelet gene expression and function in patients with COVID-19.
Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA. Manne BK, et al. Among authors: guo l. Blood. 2020 Sep 10;136(11):1317-1329. doi: 10.1182/blood.2020007214. Blood. 2020. PMID: 32573711 Free PMC article.
MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis.
Manne BK, Campbell RA, Bhatlekar S, Ajanel A, Denorme F, Portier I, Middleton EA, Tolley ND, Kosaka Y, Montenont E, Guo L, Rowley JW, Bray PF, Jacob S, Fukanaga R, Proud C, Weyrich AS, Rondina MT. Manne BK, et al. Among authors: guo l. Blood. 2022 Dec 8;140(23):2477-2489. doi: 10.1182/blood.2022015568. Blood. 2022. PMID: 35930749 Free PMC article.
Heparanase expression and activity are increased in platelets during clinical sepsis.
Eustes AS, Campbell RA, Middleton EA, Tolley ND, Manne BK, Montenont E, Rowley JW, Krauel K, Blair A, Guo L, Kosaka Y, Medeiros-de-Moraes IM, Lacerda M, Hottz ED, Neto HCF, Zimmerman GA, Weyrich AS, Petrey A, Rondina MT. Eustes AS, et al. Among authors: guo l. J Thromb Haemost. 2021 May;19(5):1319-1330. doi: 10.1111/jth.15266. Epub 2021 Mar 11. J Thromb Haemost. 2021. PMID: 33587773 Free PMC article.
Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function.
Bhatlekar S, Jacob S, Manne BK, Guo L, Denorme F, Tugolukova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, O'Connell RM, Bray PF. Bhatlekar S, et al. Among authors: guo l. Blood Cells Mol Dis. 2021 Dec;92:102624. doi: 10.1016/j.bcmd.2021.102624. Epub 2021 Nov 3. Blood Cells Mol Dis. 2021. PMID: 34775219 Free PMC article.
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