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Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles.
Rojas G, Relova-Hernández E, Pérez-Riverón A, Castro-Martínez C, Diaz-Bravo O, Infante YC, Gómez T, Solozábal J, DíazBravo AB, Schubert M, Becker M, Pérez-Massón B, Pérez-Martínez D, Alvarez-Arzola R, Guirola O, Chinea G, Graca L, Dübel S, León K, Carmenate T. Rojas G, et al. Among authors: guirola o. Commun Biol. 2023 Aug 9;6(1):828. doi: 10.1038/s42003-023-05188-0. Commun Biol. 2023. PMID: 37558752 Free PMC article.
Receptor-activated human α2-macroglobulin interacts with the envelope protein of dengue virus and protects virions from temperature-induced inactivation through multivalent binding.
Huerta V, Toledo P, Fleitas N, Martín A, Pupo D, Yero A, Sarría M, Sánchez A, Besada V, Ramos Y, Márquez G, Guirola O, Chinea G. Huerta V, et al. Among authors: guirola o. J Gen Virol. 2014 Dec;95(Pt 12):2668-2676. doi: 10.1099/vir.0.068544-0. Epub 2014 Aug 6. J Gen Virol. 2014. PMID: 25100798
An "on-matrix" digestion procedure for AP-MS experiments dissects the interplay between complex-conserved and serotype-specific reactivities in Dengue virus-human plasma interactome.
Ramos Y, Huerta V, Martín D, Palomares S, Yero A, Pupo D, Gallien S, Martín AM, Pérez-Riverol Y, Sarría M, Guirola O, Chinea G, Domon B, González LJ. Ramos Y, et al. Among authors: guirola o. J Proteomics. 2019 Feb 20;193:71-84. doi: 10.1016/j.jprot.2017.07.004. Epub 2017 Jul 13. J Proteomics. 2019. PMID: 28713027
A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C.
Masforrol Y, Gil J, García D, Noda J, Ramos Y, Betancourt L, Guirola O, González S, Acevedo B, Besada V, Reyes O, González LJ. Masforrol Y, et al. Among authors: guirola o. Hum Vaccin Immunother. 2017 Nov 2;13(11):2548-2560. doi: 10.1080/21645515.2017.1356961. Epub 2017 Oct 30. Hum Vaccin Immunother. 2017. PMID: 29083947 Free PMC article. Review.
19 results