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SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.
Lavigne M, Helynck O, Rigolet P, Boudria-Souilah R, Nowakowski M, Baron B, Brülé S, Hoos S, Raynal B, Guittat L, Beauvineau C, Petres S, Granzhan A, Guillon J, Pratviel G, Teulade-Fichou MP, England P, Mergny JL, Munier-Lehmann H. Lavigne M, et al. Among authors: guillon j. Nucleic Acids Res. 2021 Jul 21;49(13):7695-7712. doi: 10.1093/nar/gkab571. Nucleic Acids Res. 2021. PMID: 34232992 Free PMC article.
Design, Synthesis, and Evaluation of 2,9-Bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline Derivatives as G-Quadruplex Ligands.
Gueddouda NM, Hurtado MR, Moreau S, Ronga L, Das RN, Savrimoutou S, Rubio S, Marchand A, Mendoza O, Marchivie M, Elmi L, Chansavang A, Desplat V, Gabelica V, Bourdoncle A, Mergny JL, Guillon J. Gueddouda NM, et al. Among authors: guillon j. ChemMedChem. 2017 Jan 20;12(2):146-160. doi: 10.1002/cmdc.201600511. Epub 2017 Jan 3. ChemMedChem. 2017. PMID: 27917615 Free article.
Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives.
Guillon J, Cohen A, Gueddouda NM, Das RN, Moreau S, Ronga L, Savrimoutou S, Basmaciyan L, Monnier A, Monget M, Rubio S, Garnerin T, Azas N, Mergny JL, Mullié C, Sonnet P. Guillon J, et al. J Enzyme Inhib Med Chem. 2017 Dec;32(1):547-563. doi: 10.1080/14756366.2016.1268608. J Enzyme Inhib Med Chem. 2017. PMID: 28114821 Free PMC article.
Design, synthesis, and antiprotozoal evaluation of new 2,9-bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline derivatives.
Guillon J, Cohen A, Das RN, Boudot C, Gueddouda NM, Moreau S, Ronga L, Savrimoutou S, Basmaciyan L, Tisnerat C, Mestanier S, Rubio S, Amaziane S, Dassonville-Klimpt A, Azas N, Courtioux B, Mergny JL, Mullié C, Sonnet P. Guillon J, et al. Chem Biol Drug Des. 2018 May;91(5):974-995. doi: 10.1111/cbdd.13164. Epub 2018 Jan 17. Chem Biol Drug Des. 2018. PMID: 29266861
Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives.
Guillon J, Cohen A, Boudot C, Valle A, Milano V, Das RN, Guédin A, Moreau S, Ronga L, Savrimoutou S, Demourgues M, Reviriego E, Rubio S, Ferriez S, Agnamey P, Pauc C, Moukha S, Dozolme P, Nascimento SD, Laumaillé P, Bouchut A, Azas N, Mergny JL, Mullié C, Sonnet P, Courtioux B. Guillon J, et al. J Enzyme Inhib Med Chem. 2020 Dec;35(1):432-459. doi: 10.1080/14756366.2019.1706502. J Enzyme Inhib Med Chem. 2020. PMID: 31899980 Free PMC article.
Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells.
Beauvarlet J, Nath Das R, Alvarez-Valadez K, Martins I, Muller A, Darbo E, Richard E, Soubeyran P, Kroemer G, Guillon J, Mergny JL, Djavaheri-Mergny M. Beauvarlet J, et al. Among authors: guillon j. Cancers (Basel). 2020 Jun 18;12(6):1621. doi: 10.3390/cancers12061621. Cancers (Basel). 2020. PMID: 32570977 Free PMC article.
Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex.
Guillon J, Denevault-Sabourin C, Chevret E, Brachet-Botineau M, Milano V, Guédin-Beaurepaire A, Moreau S, Ronga L, Savrimoutou S, Rubio S, Ferrer J, Lamarche J, Mergny JL, Viaud-Massuard MC, Ranz M, Largy E, Gabelica V, Rosu F, Gouilleux F, Desplat V. Guillon J, et al. Arch Pharm (Weinheim). 2021 Aug;354(8):e2000450. doi: 10.1002/ardp.202000450. Epub 2021 Apr 14. Arch Pharm (Weinheim). 2021. PMID: 33852185
G-quadruplexes in helminth parasites.
Cantara A, Luo Y, Dobrovolná M, Bohalova N, Fojta M, Verga D, Guittat L, Cucchiarini A, Savrimoutou S, Häberli C, Guillon J, Keiser J, Brázda V, Mergny JL. Cantara A, et al. Among authors: guillon j. Nucleic Acids Res. 2022 Mar 21;50(5):2719-2735. doi: 10.1093/nar/gkac129. Nucleic Acids Res. 2022. PMID: 35234933 Free PMC article.
Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-Bis[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux.
Guillon J, Cohen A, Boudot C, Monic S, Savrimoutou S, Moreau S, Albenque-Rubio S, Lafon-Schmaltz C, Dassonville-Klimpt A, Mergny JL, Ronga L, Bernabeu de Maria M, Lamarche J, Lago CD, Largy E, Gabelica V, Moukha S, Dozolme P, Agnamey P, Azas N, Mullié C, Courtioux B, Sonnet P. Guillon J, et al. Pathogens. 2022 Nov 13;11(11):1339. doi: 10.3390/pathogens11111339. Pathogens. 2022. PMID: 36422591 Free PMC article.
363 results