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A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro.
De Castro S, Stevaert A, Maldonado M, Delpal A, Vandeput J, Van Loy B, Eydoux C, Guillemot JC, Decroly E, Gago F, Canard B, Camarasa MJ, Velázquez S, Naesens L. De Castro S, et al. Among authors: guillemot jc. Pharmaceuticals (Basel). 2022 Aug 18;15(8):1021. doi: 10.3390/ph15081021. Pharmaceuticals (Basel). 2022. PMID: 36015168 Free PMC article.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Bardiot D, Vangeel L, Koukni M, Arzel P, Zwaagstra M, Lyoo H, Wanningen P, Ahmad S, Zhang L, Sun X, Delpal A, Eydoux C, Guillemot JC, Lescrinier E, Klaassen H, Leyssen P, Jochmans D, Castermans K, Hilgenfeld R, Robinson C, Decroly E, Canard B, Snijder EJ, van Hemert MJ, van Kuppeveld F, Chaltin P, Neyts J, De Jonghe S, Marchand A. Bardiot D, et al. Among authors: guillemot jc. Molecules. 2022 Feb 4;27(3):1052. doi: 10.3390/molecules27031052. Molecules. 2022. PMID: 35164317 Free PMC article.
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay.
Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Quérat G, Gigante A, Pérez Pérez MJ, Jung ML, Canard B, Guillemot JC, Decroly E, Coutard B. Ferreira-Ramos AS, et al. Among authors: guillemot jc. Antiviral Res. 2019 Mar;163:59-69. doi: 10.1016/j.antiviral.2019.01.003. Epub 2019 Jan 11. Antiviral Res. 2019. PMID: 30639438
Drugs against SARS-CoV-2: What do we know about their mode of action?
Valle C, Martin B, Touret F, Shannon A, Canard B, Guillemot JC, Coutard B, Decroly E. Valle C, et al. Among authors: guillemot jc. Rev Med Virol. 2020 Nov;30(6):1-10. doi: 10.1002/rmv.2143. Epub 2020 Aug 11. Rev Med Virol. 2020. PMID: 32779326 Free PMC article. Review.
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.
Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Bouvet M, et al. Among authors: guillemot jc. J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074927 Free PMC article.
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
Benmansour F, Eydoux C, Querat G, de Lamballerie X, Canard B, Alvarez K, Guillemot JC, Barral K. Benmansour F, et al. Among authors: guillemot jc. Eur J Med Chem. 2016 Feb 15;109:146-56. doi: 10.1016/j.ejmech.2015.12.046. Epub 2015 Dec 29. Eur J Med Chem. 2016. PMID: 26774922
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B. Shannon A, et al. Among authors: guillemot jc. Nat Commun. 2022 Feb 2;13(1):621. doi: 10.1038/s41467-022-28113-1. Nat Commun. 2022. PMID: 35110538 Free PMC article.
111 results