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Page 1
Chemical genetics of Plasmodium falciparum.
Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Guiguemde WA, et al. Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099. Nature. 2010. PMID: 20485428 Free PMC article.
Global phenotypic screening for antimalarials.
Guiguemde WA, Shelat AA, Garcia-Bustos JF, Diagana TT, Gamo FJ, Guy RK. Guiguemde WA, et al. Chem Biol. 2012 Jan 27;19(1):116-29. doi: 10.1016/j.chembiol.2012.01.004. Chem Biol. 2012. PMID: 22284359 Free PMC article. Review.
Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.
Tanaka TQ, Guiguemde WA, Barnett DS, Maron MI, Min J, Connelly MC, Suryadevara PK, Guy RK, Williamson KC. Tanaka TQ, et al. Among authors: guiguemde wa. Antimicrob Agents Chemother. 2015 Mar;59(3):1389-97. doi: 10.1128/AAC.01930-13. Epub 2014 Dec 15. Antimicrob Agents Chemother. 2015. PMID: 25512421 Free PMC article.
Evaluation of Diarylureas for Activity Against Plasmodium falciparum.
Zhang Y, Anderson M, Weisman JL, Lu M, Choy CJ, Boyd VA, Price J, Sigal M, Clark J, Connelly M, Zhu F, Guiguemde WA, Jeffries C, Yang L, Lemoff A, Liou AP, Webb TR, Derisi JL, Guy RK. Zhang Y, et al. Among authors: guiguemde wa. ACS Med Chem Lett. 2010 Dec 9;1(9):460-465. doi: 10.1021/ml100083c. ACS Med Chem Lett. 2010. PMID: 21243104 Free PMC article.
Optimization of propafenone analogues as antimalarial leads.
Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. Lowes DJ, et al. Among authors: guiguemde wa. J Med Chem. 2011 Nov 10;54(21):7477-85. doi: 10.1021/jm2005546. Epub 2011 Oct 10. J Med Chem. 2011. PMID: 21955244 Free PMC article.
An all-purpose antimalarial drug target.
Guiguemde WA, Guy RK. Guiguemde WA, et al. Cell Host Microbe. 2012 Jun 14;11(6):555-7. doi: 10.1016/j.chom.2012.05.008. Cell Host Microbe. 2012. PMID: 22704614 Free article. Review.
Lead optimization of antimalarial propafenone analogues.
Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, Kyle DE, Mirsalis J, Guy RK. Lowes D, et al. Among authors: guiguemde wa. J Med Chem. 2012 Jul 12;55(13):6087-93. doi: 10.1021/jm300286a. Epub 2012 Jun 29. J Med Chem. 2012. PMID: 22708838 Free PMC article.
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