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A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1).
Mycroft-West CJ, Devlin AJ, Cooper LC, Guimond SE, Procter P, Miller GJ, Guerrini M, Fernig DG, Yates EA, Lima MA, Skidmore MA. Mycroft-West CJ, et al. Among authors: guerrini m. Carbohydr Res. 2023 Mar;525:108747. doi: 10.1016/j.carres.2023.108747. Epub 2023 Jan 26. Carbohydr Res. 2023. PMID: 36773398
Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution.
Guimond SE, Rudd TR, Skidmore MA, Ori A, Gaudesi D, Cosentino C, Guerrini M, Edge R, Collison D, McInnes E, Torri G, Turnbull JE, Fernig DG, Yates EA. Guimond SE, et al. Among authors: guerrini m. Biochemistry. 2009 Jun 9;48(22):4772-9. doi: 10.1021/bi802318z. Biochemistry. 2009. PMID: 19400583
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships.
Rudd TR, Uniewicz KA, Ori A, Guimond SE, Skidmore MA, Gaudesi D, Xu R, Turnbull JE, Guerrini M, Torri G, Siligardi G, Wilkinson MC, Fernig DG, Yates EA. Rudd TR, et al. Among authors: guerrini m. Org Biomol Chem. 2010 Dec 7;8(23):5390-7. doi: 10.1039/c0ob00246a. Epub 2010 Sep 3. Org Biomol Chem. 2010. PMID: 20865198
259 results