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Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption.
Cawley KM, Bustamante-Gomez NC, Guha AG, MacLeod RS, Xiong J, Gubrij I, Liu Y, Mulkey R, Palmieri M, Thostenson JD, Goellner JJ, O'Brien CA. Cawley KM, et al. Among authors: gubrij i. Cell Rep. 2020 Sep 8;32(10):108052. doi: 10.1016/j.celrep.2020.108052. Cell Rep. 2020. PMID: 32905775 Free PMC article.
Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Bellido T, et al. Among authors: gubrij i. J Biol Chem. 2003 Dec 12;278(50):50259-72. doi: 10.1074/jbc.M307444200. Epub 2003 Oct 1. J Biol Chem. 2003. PMID: 14523023 Free article.
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone.
O'Brien CA, Gubrij I, Lin SC, Saylors RL, Manolagas SC. O'Brien CA, et al. Among authors: gubrij i. J Biol Chem. 1999 Jul 2;274(27):19301-8. doi: 10.1074/jbc.274.27.19301. J Biol Chem. 1999. PMID: 10383440 Free article.
14 results