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SFCE-RAPIRI Phase I Study of Rapamycin Plus Irinotecan: A New Way to Target Intra-Tumor Hypoxia in Pediatric Refractory Cancers.
Jannier S, Kemmel V, Sebastia Sancho C, Chammas A, Sabo AN, Pencreach E, Farace F, Chenard MP, Lhermitte B, Geoerger B, Aerts I, Frappaz D, Leblond P, André N, Ducassou S, Corradini N, Bertozzi AI, Guérin E, Vincent F, Velten M, Entz-Werle N. Jannier S, et al. Among authors: guerin e. Cancers (Basel). 2020 Oct 20;12(10):3051. doi: 10.3390/cancers12103051. Cancers (Basel). 2020. PMID: 33092063 Free PMC article.
Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis.
Pencreach E, Guérin E, Nicolet C, Lelong-Rebel I, Voegeli AC, Oudet P, Larsen AK, Gaub MP, Guenot D. Pencreach E, et al. Among authors: guerin e. Clin Cancer Res. 2009 Feb 15;15(4):1297-307. doi: 10.1158/1078-0432.CCR-08-0889. Epub 2009 Feb 3. Clin Cancer Res. 2009. PMID: 19190131
Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.
Janouskova H, Maglott A, Leger DY, Bossert C, Noulet F, Guerin E, Guenot D, Pinel S, Chastagner P, Plenat F, Entz-Werle N, Lehmann-Che J, Godet J, Martin S, Teisinger J, Dontenwill M. Janouskova H, et al. Among authors: guerin e. Cancer Res. 2012 Jul 15;72(14):3463-70. doi: 10.1158/0008-5472.CAN-11-4199. Epub 2012 May 16. Cancer Res. 2012. PMID: 22593187
Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition.
Nguyen A, Moussallieh FM, Mackay A, Cicek AE, Coca A, Chenard MP, Weingertner N, Lhermitte B, Letouzé E, Guérin E, Pencreach E, Jannier S, Guenot D, Namer IJ, Jones C, Entz-Werlé N. Nguyen A, et al. Among authors: guerin e. Oncotarget. 2017 Mar 23;8(42):71597-71617. doi: 10.18632/oncotarget.16500. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069732 Free PMC article.
197 results