The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth.
Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU, Grumet M.
Friedlander DR, et al. Among authors: grumet m.
J Cell Biol. 1994 May;125(3):669-80. doi: 10.1083/jcb.125.3.669.
J Cell Biol. 1994.
PMID: 7513709
Free PMC article.
We have previously shown that aggregation of microbeads coated with N-CAM and Ng-CAM is inhibited by incubation with soluble neurocan, a chondroitin sulfate proteoglycan of brain, suggesting that neurocan binds to these cell adhesion molecules (Grumet, M., A. Flaccu …
We have previously shown that aggregation of microbeads coated with N-CAM and Ng-CAM is inhibited by incubation with soluble neurocan, a cho …