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Cryo-EM structure of CtBP2 confirms tetrameric architecture.
Jecrois AM, Dcona MM, Deng X, Bandyopadhyay D, Grossman SR, Schiffer CA, Royer WE Jr. Jecrois AM, et al. Among authors: grossman sr. Structure. 2021 Apr 1;29(4):310-319.e5. doi: 10.1016/j.str.2020.11.008. Epub 2020 Dec 1. Structure. 2021. PMID: 33264605 Free PMC article.
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities.
Dcona MM, Damle PK, Zarate-Perez F, Morris BL, Nawaz Z, Dennis MJ, Deng X, Korwar S, Singh SJ, Ellis KC, Royer WE, Bandyopadhyay D, Escalante C, Grossman SR. Dcona MM, et al. Among authors: grossman sr. Mol Pharmacol. 2019 Jul;96(1):99-108. doi: 10.1124/mol.118.114363. Epub 2019 Apr 29. Mol Pharmacol. 2019. PMID: 31036695 Free PMC article.
Structure-guided design of a high affinity inhibitor to human CtBP.
Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE Jr. Hilbert BJ, et al. Among authors: grossman sr. ACS Chem Biol. 2015 Apr 17;10(4):1118-27. doi: 10.1021/cb500820b. Epub 2015 Jan 30. ACS Chem Biol. 2015. PMID: 25636004 Free PMC article.
Therapeutic targeting of C-terminal binding protein in human cancer.
Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR. Straza MW, et al. Among authors: grossman sr. Cell Cycle. 2010 Sep 15;9(18):3740-50. doi: 10.4161/cc.9.18.12936. Epub 2010 Sep 8. Cell Cycle. 2010. PMID: 20930544 Free PMC article.
Phase 1 Study of Neoadjuvant Short-Course Radiation Therapy Concurrent With Infusional 5-Fluorouracil for the Treatment of Locally Advanced Rectal Cancer.
Fields EC, Kaplan BJ, Karlin J, Myers JL, Mukhopadhyay N, Deng X, Sankala H, Grossman SR, Matin K. Fields EC, et al. Among authors: grossman sr. Adv Radiat Oncol. 2019 May 11;4(4):605-612. doi: 10.1016/j.adro.2019.04.005. eCollection 2019 Oct-Dec. Adv Radiat Oncol. 2019. PMID: 31673654 Free PMC article.
115 results