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Glycolysis is integral to histamine-induced endothelial hyperpermeability.
Ziogas A, Sajib MS, Lim JH, Alves TC, Das A, Witt A, Hagag E, Androulaki N, Grossklaus S, Gerlach M, Noll T, Grinenko T, Mirtschink P, Hajishengallis G, Chavakis T, Mikelis CM, Sprott D. Ziogas A, et al. Among authors: grossklaus s. FASEB J. 2021 Mar;35(3):e21425. doi: 10.1096/fj.202001634R. FASEB J. 2021. PMID: 33566443 Free PMC article.
DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1.
Ziogas A, Maekawa T, Wiessner JR, Le TT, Sprott D, Troullinaki M, Neuwirth A, Anastasopoulou V, Grossklaus S, Chung KJ, Sperandio M, Chavakis T, Hajishengallis G, Alexaki VI. Ziogas A, et al. Among authors: grossklaus s. J Immunol. 2020 Mar 1;204(5):1214-1224. doi: 10.4049/jimmunol.1900746. Epub 2020 Jan 24. J Immunol. 2020. PMID: 31980574 Free PMC article.
Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis.
Wang H, Li X, Kajikawa T, Shin J, Lim JH, Kourtzelis I, Nagai K, Korostoff JM, Grossklaus S, Naumann R, Chavakis T, Hajishengallis G. Wang H, et al. Among authors: grossklaus s. J Clin Invest. 2021 Oct 1;131(19):e150578. doi: 10.1172/JCI150578. J Clin Invest. 2021. PMID: 34403362 Free PMC article.
Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy.
Economopoulou M, Avramovic N, Klotzsche-von Ameln A, Korovina I, Sprott D, Samus M, Gercken B, Troullinaki M, Grossklaus S, Funk RH, Li X, Imhof BA, Orlova VV, Chavakis T. Economopoulou M, et al. Among authors: grossklaus s. Thromb Haemost. 2015 Nov 25;114(6):1241-9. doi: 10.1160/TH15-01-0051. Epub 2015 Aug 27. Thromb Haemost. 2015. PMID: 26311310
DEL-1 promotes macrophage efferocytosis and clearance of inflammation.
Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. Kourtzelis I, et al. Among authors: grossklaus s. Nat Immunol. 2019 Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19. Nat Immunol. 2019. PMID: 30455459 Free PMC article.
DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.
Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T. Alexaki VI, et al. Among authors: grossklaus s. Mol Psychiatry. 2018 Jun;23(6):1410-1420. doi: 10.1038/mp.2017.167. Epub 2017 Sep 12. Mol Psychiatry. 2018. PMID: 28894299
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