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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.
Duan J, Matute JD, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, Grootjans J, Pyzik M, Sommer F, Kaiser S, Falk-Paulsen M, Grasberger H, Kao JY, Fuhrer T, Li H, Paik D, Lee Y, Refetoff S, Glickman JN, Paton AW, Bry L, Paton JC, Sauer U, Macpherson AJ, Rosenstiel P, Kuchroo VK, Waldor MK, Huh JR, Kaser A, Blumberg RS. Duan J, et al. Among authors: grootjans j. Immunity. 2023 May 9;56(5):1115-1131.e9. doi: 10.1016/j.immuni.2023.02.018. Epub 2023 Mar 13. Immunity. 2023. PMID: 36917985 Free PMC article.
The unfolded protein response in immunity and inflammation.
Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. Grootjans J, et al. Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Nat Rev Immunol. 2016. PMID: 27346803 Free PMC article. Review.
Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation.
Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R. Hosomi S, et al. Among authors: grootjans j. J Exp Med. 2017 Oct 2;214(10):2985-2997. doi: 10.1084/jem.20162041. Epub 2017 Jul 26. J Exp Med. 2017. PMID: 28747426 Free PMC article.
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.
Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. Grootjans J, et al. Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186. Science. 2019. PMID: 30819965 Free PMC article.
Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.
Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS. Matute JD, et al. Among authors: grootjans j. J Exp Med. 2023 Jan 2;220(1):e20211938. doi: 10.1084/jem.20211938. Epub 2022 Nov 22. J Exp Med. 2023. PMID: 36413219 Free PMC article.
55 results