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M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
Rao SD, Chen Q, Wang Q, Orth-He EL, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Huang HC, Chui AJ, Covelli DJ, You S, Cross JR, Bachovchin DA. Rao SD, et al. Among authors: griswold ar. Nat Chem Biol. 2022 May;18(5):565-574. doi: 10.1038/s41589-021-00964-7. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165443 Free PMC article.
Activation of the CARD8 Inflammasome Requires a Disordered Region.
Chui AJ, Griswold AR, Taabazuing CY, Orth EL, Gai K, Rao SD, Ball DP, Hsiao JC, Bachovchin DA. Chui AJ, et al. Among authors: griswold ar. Cell Rep. 2020 Oct 13;33(2):108264. doi: 10.1016/j.celrep.2020.108264. Cell Rep. 2020. PMID: 33053349 Free PMC article.
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.
Ball DP, Tsamouri LP, Wang AE, Huang HC, Warren CD, Wang Q, Edmondson IH, Griswold AR, Rao SD, Johnson DC, Bachovchin DA. Ball DP, et al. Among authors: griswold ar. Sci Immunol. 2022 Nov 11;7(77):eabm7200. doi: 10.1126/sciimmunol.abm7200. Epub 2022 Nov 4. Sci Immunol. 2022. PMID: 36332009 Free PMC article.
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H. Hollingsworth LR, et al. Among authors: griswold ar. Nature. 2021 Apr;592(7856):778-783. doi: 10.1038/s41586-021-03350-4. Epub 2021 Mar 17. Nature. 2021. PMID: 33731932 Free PMC article.
The NLRP1 and CARD8 inflammasomes.
Taabazuing CY, Griswold AR, Bachovchin DA. Taabazuing CY, et al. Among authors: griswold ar. Immunol Rev. 2020 Sep;297(1):13-25. doi: 10.1111/imr.12884. Epub 2020 Jun 19. Immunol Rev. 2020. PMID: 32558991 Free PMC article. Review.
20 results