Greenleaf WJ - Search Results

1

Aging-associated HELIOS deficiency in naive CD4⁺ T cells alters chromatin remodeling and promotes effector cell responses.

Zhang H, Jadhav RR, Cao W, Goronzy IN, Zhao TV, Jin J, Ohtsuki S, Hu Z, Morales J, Greenleaf WJ, Weyand CM, Goronzy JJ. Zhang H, et al. Among authors: greenleaf wj. Nat Immunol. 2023 Jan;24(1):96-109. doi: 10.1038/s41590-022-01369-x. Epub 2022 Dec 12. Nat Immunol. 2023. PMID: 36510022 Free PMC article.

2

Epigenomics of human CD8 T cell differentiation and aging.

Moskowitz DM, Zhang DW, Hu B, Le Saux S, Yanes RE, Ye Z, Buenrostro JD, Weyand CM, Greenleaf WJ, Goronzy JJ. Moskowitz DM, et al. Among authors: greenleaf wj. Sci Immunol. 2017 Feb;2(8):eaag0192. doi: 10.1126/sciimmunol.aag0192. Epub 2017 Feb 17. Sci Immunol. 2017. PMID: 28439570 Free PMC article.

3

Origin and differentiation of human memory CD8 T cells after vaccination.

Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R. Akondy RS, et al. Among authors: greenleaf wj. Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13. Nature. 2017. PMID: 29236685 Free PMC article.

4

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade.

Jadhav RR, Im SJ, Hu B, Hashimoto M, Li P, Lin JX, Leonard WJ, Greenleaf WJ, Ahmed R, Goronzy JJ. Jadhav RR, et al. Among authors: greenleaf wj. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14113-14118. doi: 10.1073/pnas.1903520116. Epub 2019 Jun 21. Proc Natl Acad Sci U S A. 2019. PMID: 31227606 Free PMC article.

5

Reduced chromatin accessibility to CD4 T cell super-enhancers encompassing susceptibility loci of rheumatoid arthritis.

Jadhav RR, Hu B, Ye Z, Sheth K, Li X, Greenleaf WJ, Weyand CM, Goronzy JJ. Jadhav RR, et al. Among authors: greenleaf wj. EBioMedicine. 2022 Feb;76:103825. doi: 10.1016/j.ebiom.2022.103825. Epub 2022 Jan 24. EBioMedicine. 2022. PMID: 35085847 Free PMC article.

6

NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells.

Chen AF, Parks B, Kathiria AS, Ober-Reynolds B, Goronzy JJ, Greenleaf WJ. Chen AF, et al. Among authors: greenleaf wj. Nat Methods. 2022 May;19(5):547-553. doi: 10.1038/s41592-022-01461-y. Epub 2022 May 2. Nat Methods. 2022. PMID: 35501385

7

PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program.

Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgräber V, Greenleaf WJ, Klein C, Goronzy JJ, Umaña P, Leonard WJ, Smith KA, Ahmed R. Hashimoto M, et al. Among authors: greenleaf wj. Nature. 2022 Oct;610(7930):173-181. doi: 10.1038/s41586-022-05257-0. Epub 2022 Sep 28. Nature. 2022. PMID: 36171288 Free PMC article.

8

PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape.

Gamble N, Bradu A, Caldwell JA, McKeever J, Bolonduro O, Ermis E, Kaiser C, Kim Y, Parks B, Klemm S, Greenleaf WJ, Crabtree GR, Koh AS. Gamble N, et al. Among authors: greenleaf wj. Nat Immunol. 2024 May;25(5):860-872. doi: 10.1038/s41590-024-01807-y. Epub 2024 Apr 17. Nat Immunol. 2024. PMID: 38632339 Free PMC article.

9

Direct observation of base-pair stepping by RNA polymerase.

Abbondanzieri EA, Greenleaf WJ, Shaevitz JW, Landick R, Block SM. Abbondanzieri EA, et al. Among authors: greenleaf wj. Nature. 2005 Nov 24;438(7067):460-5. doi: 10.1038/nature04268. Epub 2005 Nov 13. Nature. 2005. PMID: 16284617 Free PMC article.

10

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position.

Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ. Buenrostro JD, et al. Among authors: greenleaf wj. Nat Methods. 2013 Dec;10(12):1213-8. doi: 10.1038/nmeth.2688. Epub 2013 Oct 6. Nat Methods. 2013. PMID: 24097267 Free PMC article.

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