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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Among authors: greengard p. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.
A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase.
Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. Luo W, et al. Among authors: greengard p. ACS Chem Neurosci. 2020 Sep 16;11(18):2827-2835. doi: 10.1021/acschemneuro.0c00389. Epub 2020 Sep 3. ACS Chem Neurosci. 2020. PMID: 32786303 Free PMC article.
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P. Ledo JH, et al. Among authors: greengard p. Mol Psychiatry. 2021 Oct;26(10):5620-5635. doi: 10.1038/s41380-020-0856-8. Epub 2020 Aug 13. Mol Psychiatry. 2021. PMID: 32792660 Free PMC article.
APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y. Ceglia I, et al. Among authors: greengard p. Nat Med. 2015 Sep;21(9):1054-9. doi: 10.1038/nm.3924. Epub 2015 Aug 17. Nat Med. 2015. PMID: 26280122 Free PMC article.
The dentate gyrus in depression.
Umschweif G, Greengard P, Sagi Y. Umschweif G, et al. Among authors: greengard p. Eur J Neurosci. 2021 Jan;53(1):39-64. doi: 10.1111/ejn.14640. Epub 2019 Dec 20. Eur J Neurosci. 2021. PMID: 31811730 Review.
950 results