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Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR, Wielscher M, Yew YW, Baumbach C, Lee DP, Marouli E, Bernard M, Pfeiffer L, Matías-García PR, Autio MI, Bourgeois S, Herder C, Karhunen V, Meitinger T, Prokisch H, Rathmann W, Roden M, Sebert S, Shin J, Strauch K, Zhang W, Tan WLW, Hauck SM, Merl-Pham J, Grallert H, Barbosa EGV; MuTHER Consortium; Illig T, Peters A, Paus T, Pausova Z, Deloukas P, Foo RSY, Jarvelin MR, Kooner JS, Loh M, Heinig M, Gieger C, Waldenberger M, Chambers JC. Hawe JS, et al. Among authors: grallert h. Nat Genet. 2022 Jan;54(1):18-29. doi: 10.1038/s41588-021-00969-x. Epub 2022 Jan 3. Nat Genet. 2022. PMID: 34980917
Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations.
Nitz I, Fisher E, Grallert H, Li Y, Gieger C, Rubin D, Boeing H, Spranger J, Lindner I, Schreiber S, Rathmann W, Gohlke H, Döring A, Wichmann HE, Schrezenmeir J, Döring F, Illig T. Nitz I, et al. Among authors: grallert h. J Clin Endocrinol Metab. 2007 Aug;92(8):3183-8. doi: 10.1210/jc.2006-2550. Epub 2007 Jun 12. J Clin Endocrinol Metab. 2007. PMID: 17566096
Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).
Holzapfel C, Klopp N, Grallert H, Huth C, Gieger C, Meisinger C, Strassburger K, Giani G, Wichmann HE, Laumen H, Hauner H, Herder C, Rathmann W, Illig T. Holzapfel C, et al. Among authors: grallert h. Eur J Endocrinol. 2007 Sep;157(3):R1-5. doi: 10.1530/EJE-07-0297. Eur J Endocrinol. 2007. PMID: 17766704
APOA5 variants and metabolic syndrome in Caucasians.
Grallert H, Sedlmeier EM, Huth C, Kolz M, Heid IM, Meisinger C, Herder C, Strassburger K, Gehringer A, Haak M, Giani G, Kronenberg F, Wichmann HE, Adamski J, Paulweber B, Illig T, Rathmann W. Grallert H, et al. J Lipid Res. 2007 Dec;48(12):2614-21. doi: 10.1194/jlr.M700011-JLR200. Epub 2007 Sep 3. J Lipid Res. 2007. PMID: 17768309 Free article.
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium; Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D. Zeggini E, et al. Among authors: grallert h. Nat Genet. 2008 May;40(5):638-45. doi: 10.1038/ng.120. Epub 2008 Mar 30. Nat Genet. 2008. PMID: 18372903 Free PMC article.
Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
Holzapfel C, Baumert J, Grallert H, Müller AM, Thorand B, Khuseyinova N, Herder C, Meisinger C, Hauner H, Wichmann HE, Koenig W, Illig T, Klopp N. Holzapfel C, et al. Among authors: grallert h. Eur J Endocrinol. 2008 Oct;159(4):407-16. doi: 10.1530/EJE-08-0356. Epub 2008 Jul 1. Eur J Endocrinol. 2008. PMID: 18593823
318 results