Graham RK - Search Results

1

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.

Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW. Saleh M, et al. Among authors: graham rk. Nature. 2004 May 6;429(6987):75-9. doi: 10.1038/nature02451. Nature. 2004. PMID: 15129283 Free article.

2

Caspase-6 and neurodegeneration.

Graham RK, Ehrnhoefer DE, Hayden MR. Graham RK, et al. Trends Neurosci. 2011 Dec;34(12):646-56. doi: 10.1016/j.tins.2011.09.001. Epub 2011 Oct 22. Trends Neurosci. 2011. PMID: 22018804 Review.

3

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JP, Hayden MR. Goldberg YP, et al. Among authors: graham rk. Nat Genet. 1996 Aug;13(4):442-9. doi: 10.1038/ng0896-442. Nat Genet. 1996. PMID: 8696339

4

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. Among authors: graham rk. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.

5

To be or not to be toxic: aggregations in Huntington and Alzheimer disease.

Slow EJ, Graham RK, Hayden MR. Slow EJ, et al. Among authors: graham rk. Trends Genet. 2006 Aug;22(8):408-11. doi: 10.1016/j.tig.2006.05.008. Epub 2006 Jun 27. Trends Genet. 2006. PMID: 16806565

6

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Graham RK, et al. Cell. 2006 Jun 16;125(6):1179-91. doi: 10.1016/j.cell.2006.04.026. Cell. 2006. PMID: 16777606 Free article.

7

Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.

Weber B, Riess O, Wolff G, Andrew S, Collins C, Graham R, Theilmann J, Hayden MR. Weber B, et al. Nat Genet. 1992 Nov;2(3):216-22. doi: 10.1038/ng1192-216. Nat Genet. 1992. PMID: 1345172

8

Wild-type huntingtin protects neurons from excitotoxicity.

Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR. Leavitt BR, et al. Among authors: graham rk. J Neurochem. 2006 Feb;96(4):1121-9. doi: 10.1111/j.1471-4159.2005.03605.x. Epub 2006 Jan 17. J Neurochem. 2006. PMID: 16417581 Free article.

9

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Metzler M, Bissada N, Wang L, Faull RL, Gray M, Yang XW, Raymond LA, Hayden MR. Graham RK, et al. J Neurosci. 2010 Nov 10;30(45):15019-29. doi: 10.1523/JNEUROSCI.2071-10.2010. J Neurosci. 2010. PMID: 21068307 Free PMC article.

10

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.

Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR. Warby SC, et al. Among authors: graham rk. Hum Mol Genet. 2008 Aug 1;17(15):2390-404. doi: 10.1093/hmg/ddn139. Epub 2008 Apr 29. Hum Mol Genet. 2008. PMID: 18445618

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