Grabow S - Search Results

1

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Kelly GL, et al. Among authors: grabow s. Genes Dev. 2014 Jan 1;28(1):58-70. doi: 10.1101/gad.232009.113. Genes Dev. 2014. PMID: 24395247 Free PMC article.

2

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.

Grabow S, Delbridge AR, Valente LJ, Strasser A. Grabow S, et al. Blood. 2014 Dec 18;124(26):3939-46. doi: 10.1182/blood-2014-09-601567. Epub 2014 Nov 3. Blood. 2014. PMID: 25368374 Free article.

3

Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53.

Valente LJ, Grabow S, Vandenberg CJ, Strasser A, Janic A. Valente LJ, et al. Among authors: grabow s. Oncogene. 2016 Jul 21;35(29):3866-71. doi: 10.1038/onc.2015.457. Epub 2015 Dec 7. Oncogene. 2016. PMID: 26640149

4

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.

Grabow S, Kelly GL, Delbridge AR, Kelly PN, Bouillet P, Adams JM, Strasser A. Grabow S, et al. Cell Death Dis. 2016 Mar 10;7(3):e2132. doi: 10.1038/cddis.2016.43. Cell Death Dis. 2016. PMID: 26962682 Free PMC article.

5

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

Delbridge AR, Pang SH, Vandenberg CJ, Grabow S, Aubrey BJ, Tai L, Herold MJ, Strasser A. Delbridge AR, et al. Among authors: grabow s. J Exp Med. 2016 Sep 19;213(10):2039-48. doi: 10.1084/jem.20150477. Epub 2016 Sep 12. J Exp Med. 2016. PMID: 27621418 Free PMC article.

6

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.

Grabow S, Delbridge AR, Aubrey BJ, Vandenberg CJ, Strasser A. Grabow S, et al. Cell Rep. 2016 Mar 15;14(10):2337-47. doi: 10.1016/j.celrep.2016.02.039. Epub 2016 Mar 3. Cell Rep. 2016. PMID: 26947081 Free article.

7

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: grabow s. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.

8

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice.

Kelly PN, Grabow S, Delbridge AR, Adams JM, Strasser A. Kelly PN, et al. Among authors: grabow s. Cell Death Differ. 2013 Jan;20(1):57-63. doi: 10.1038/cdd.2012.92. Epub 2012 Jul 20. Cell Death Differ. 2013. PMID: 22814621 Free PMC article.

9

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis.

Delbridge AR, Grabow S, Bouillet P, Adams JM, Strasser A. Delbridge AR, et al. Among authors: grabow s. Oncogene. 2015 Apr 2;34(14):1872-6. doi: 10.1038/onc.2014.132. Epub 2014 May 26. Oncogene. 2015. PMID: 24858047

10

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

O' Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang JG, Belz GT, Smyth MJ, Bouillet P, Robb L, Strasser A. O' Reilly LA, et al. Among authors: grabow s. Nature. 2009 Oct 1;461(7264):659-63. doi: 10.1038/nature08402. Nature. 2009. PMID: 19794494 Free PMC article.

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