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Mitochondrial energetics is impaired in vivo in aged skeletal muscle.
Gouspillou G, Bourdel-Marchasson I, Rouland R, Calmettes G, Biran M, Deschodt-Arsac V, Miraux S, Thiaudiere E, Pasdois P, Detaille D, Franconi JM, Babot M, Trézéguet V, Arsac L, Diolez P. Gouspillou G, et al. Aging Cell. 2014 Feb;13(1):39-48. doi: 10.1111/acel.12147. Epub 2013 Sep 19. Aging Cell. 2014. PMID: 23919652 Free PMC article.
Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.
Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT. Gouspillou G, et al. Sci Rep. 2015 Mar 3;5:8717. doi: 10.1038/srep08717. Sci Rep. 2015. PMID: 25732599 Free PMC article.
Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice.
Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, Robitaille R, St-Pierre DH, Gouspillou G. Leduc-Gaudet JP, et al. Among authors: gouspillou g. Oncotarget. 2015 Jul 20;6(20):17923-37. doi: 10.18632/oncotarget.4235. Oncotarget. 2015. PMID: 26053100 Free PMC article.
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.
Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT. Spendiff S, et al. Among authors: gouspillou g. J Physiol. 2016 Dec 15;594(24):7361-7379. doi: 10.1113/JP272487. Epub 2016 Oct 23. J Physiol. 2016. PMID: 27619626 Free PMC article.
The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men.
St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovilé I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. St-Jean-Pelletier F, et al. Among authors: gouspillou g. J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):213-228. doi: 10.1002/jcsm.12139. Epub 2016 Sep 2. J Cachexia Sarcopenia Muscle. 2017. PMID: 27897402 Free PMC article.
Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity.
Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC. Morrow RM, et al. Among authors: gouspillou g. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2705-2710. doi: 10.1073/pnas.1700997114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223503 Free PMC article.
[Skeletal muscle aging and mitochondrial dysfunction: an update].
Faitg J, Reynaud O, Leduc-Gaudet JP, Gouspillou G. Faitg J, et al. Among authors: gouspillou g. Med Sci (Paris). 2017 Nov;33(11):955-962. doi: 10.1051/medsci/20173311012. Epub 2017 Dec 4. Med Sci (Paris). 2017. PMID: 29200393 Free article. Review. French.
70 results