Gotthardt M - Search Results

1

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.

Grosch M, Schraft L, Chan A, Küchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Krämer C, Clauder-Münster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D, Steinmetz LM. Grosch M, et al. Among authors: gotthardt m. Nat Commun. 2023 Jun 22;14(1):3714. doi: 10.1038/s41467-023-39352-1. Nat Commun. 2023. PMID: 37349314 Free PMC article.

2

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.

Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M. Radke MH, et al. Among authors: gotthardt m. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3444-9. doi: 10.1073/pnas.0608543104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360664 Free PMC article.

3

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.

Lisewski U, Shi Y, Wrackmeyer U, Fischer R, Chen C, Schirdewan A, Jüttner R, Rathjen F, Poller W, Radke MH, Gotthardt M. Lisewski U, et al. Among authors: gotthardt m. J Exp Med. 2008 Sep 29;205(10):2369-79. doi: 10.1084/jem.20080897. Epub 2008 Sep 15. J Exp Med. 2008. PMID: 18794341 Free PMC article.

4

Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo.

Shi Y, Chen C, Lisewski U, Wrackmeyer U, Radke M, Westermann D, Sauter M, Tschöpe C, Poller W, Klingel K, Gotthardt M. Shi Y, et al. Among authors: gotthardt m. J Am Coll Cardiol. 2009 Apr 7;53(14):1219-26. doi: 10.1016/j.jacc.2008.10.064. J Am Coll Cardiol. 2009. PMID: 19341864 Free article.

5

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M. Granzier HL, et al. Among authors: gotthardt m. Circ Res. 2009 Sep 11;105(6):557-64. doi: 10.1161/CIRCRESAHA.109.200964. Epub 2009 Aug 13. Circ Res. 2009. PMID: 19679835 Free PMC article.

6

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.

da Silva Lopes K, Pietas A, Radke MH, Gotthardt M. da Silva Lopes K, et al. Among authors: gotthardt m. J Cell Biol. 2011 May 16;193(4):785-98. doi: 10.1083/jcb.201010099. Epub 2011 May 9. J Cell Biol. 2011. PMID: 21555460 Free PMC article.

7

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL. Chung CS, et al. Among authors: gotthardt m. J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16. J Mol Cell Cardiol. 2011. PMID: 21708170 Free PMC article.

8

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.

Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M. Guo W, et al. Among authors: gotthardt m. Nat Med. 2012 May;18(5):766-73. doi: 10.1038/nm.2693. Nat Med. 2012. PMID: 22466703 Free PMC article.

9

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.

Maatz H, Jens M, Liss M, Schafer S, Heinig M, Kirchner M, Adami E, Rintisch C, Dauksaite V, Radke MH, Selbach M, Barton PJ, Cook SA, Rajewsky N, Gotthardt M, Landthaler M, Hubner N. Maatz H, et al. Among authors: gotthardt m. J Clin Invest. 2014 Aug;124(8):3419-30. doi: 10.1172/JCI74523. Epub 2014 Jun 24. J Clin Invest. 2014. PMID: 24960161 Free PMC article.

10

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.

Elhamine F, Radke MH, Pfitzer G, Granzier H, Gotthardt M, Stehle R. Elhamine F, et al. Among authors: gotthardt m. J Cell Sci. 2014 Sep 1;127(Pt 17):3666-74. doi: 10.1242/jcs.141796. Epub 2014 Jun 30. J Cell Sci. 2014. PMID: 24982444 Free PMC article.

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