Gosselin F - Search Results

1

Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands.

Dotson JJ, van Dijk L, Timmerman JC, Grosslight S, Walroth RC, Gosselin F, Püntener K, Mack KA, Sigman MS. Dotson JJ, et al. Among authors: gosselin f. J Am Chem Soc. 2023 Jan 11;145(1):110-121. doi: 10.1021/jacs.2c08513. Epub 2022 Dec 27. J Am Chem Soc. 2023. PMID: 36574729 Free PMC article.

2

Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling.

Li BX, Le DN, Mack KA, McClory A, Lim NK, Cravillion T, Savage S, Han C, Collum DB, Zhang H, Gosselin F. Li BX, et al. Among authors: gosselin f. J Am Chem Soc. 2017 Aug 9;139(31):10777-10783. doi: 10.1021/jacs.7b05071. Epub 2017 Jul 26. J Am Chem Soc. 2017. PMID: 28715208 Free PMC article.

3

Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities.

Mack KA, McClory A, Zhang H, Gosselin F, Collum DB. Mack KA, et al. Among authors: gosselin f. J Am Chem Soc. 2017 Sep 6;139(35):12182-12189. doi: 10.1021/jacs.7b05057. Epub 2017 Aug 23. J Am Chem Soc. 2017. PMID: 28786667 Free PMC article.

4

Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers.

White NA, Clagg K, Sirois LE, Mack KA, Al-Sayah MA, Nack WA, O'Shea PD, Zhang H, Gosselin F. White NA, et al. Among authors: gosselin f. Org Lett. 2019 Dec 6;21(23):9527-9531. doi: 10.1021/acs.orglett.9b03702. Epub 2019 Nov 18. Org Lett. 2019. PMID: 31738563

5

Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins.

Bigler R, Mack KA, Shen J, Tosatti P, Han C, Bachmann S, Zhang H, Scalone M, Pfaltz A, Denmark SE, Hildbrand S, Gosselin F. Bigler R, et al. Among authors: gosselin f. Angew Chem Int Ed Engl. 2020 Feb 10;59(7):2844-2849. doi: 10.1002/anie.201912640. Epub 2020 Jan 21. Angew Chem Int Ed Engl. 2020. PMID: 31794118 Free PMC article.

6

Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings.

Zell D, Kingston C, Jermaks J, Smith SR, Seeger N, Wassmer J, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Zell D, et al. Among authors: gosselin f. J Am Chem Soc. 2021 Nov 17;143(45):19078-19090. doi: 10.1021/jacs.1c08399. Epub 2021 Nov 4. J Am Chem Soc. 2021. PMID: 34735129

7

Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics.

Molinaro C, Kawasaki Y, Wanyoike G, Nishioka T, Yamamoto T, Snedecor B, Robinson SJ, Gosselin F. Molinaro C, et al. Among authors: gosselin f. J Am Chem Soc. 2022 Aug 17;144(32):14838-14845. doi: 10.1021/jacs.2c06019. Epub 2022 Jul 29. J Am Chem Soc. 2022. PMID: 35905381

8

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

Xu J, Grosslight S, Mack KA, Nguyen SC, Clagg K, Lim NK, Timmerman JC, Shen J, White NA, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Xu J, et al. Among authors: gosselin f. J Am Chem Soc. 2022 Nov 16;144(45):20955-20963. doi: 10.1021/jacs.2c09917. Epub 2022 Nov 3. J Am Chem Soc. 2022. PMID: 36326518

9

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

Xu J, Lim NK, Timmerman JC, Shen J, Clagg K, Orcel U, Bigler R, Trachsel E, Meier R, White NA, Burkhard JA, Sirois LE, Tian Q, Angelaud R, Bachmann S, Zhang H, Gosselin F. Xu J, et al. Among authors: gosselin f. Org Lett. 2023 May 19;25(19):3417-3422. doi: 10.1021/acs.orglett.3c00961. Epub 2023 May 10. Org Lett. 2023. PMID: 37162129

10

Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides.

van Dijk L, Haas BC, Lim NK, Clagg K, Dotson JJ, Treacy SM, Piechowicz KA, Roytman VA, Zhang H, Toste FD, Miller SJ, Gosselin F, Sigman MS. van Dijk L, et al. Among authors: gosselin f. J Am Chem Soc. 2023 Sep 27;145(38):20959-20967. doi: 10.1021/jacs.3c06674. Epub 2023 Sep 1. J Am Chem Soc. 2023. PMID: 37656964

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