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Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Conlon TM, John-Schuster G, Heide D, Pfister D, Lehmann M, Hu Y, Ertüz Z, Lopez MA, Ansari M, Strunz M, Mayr C, Angelidis I, Ciminieri C, Costa R, Kohlhepp MS, Guillot A, Günes G, Jeridi A, Funk MC, Beroshvili G, Prokosch S, Hetzer J, Verleden SE, Alsafadi H, Lindner M, Burgstaller G, Becker L, Irmler M, Dudek M, Janzen J, Goffin E, Gosens R, Knolle P, Pirotte B, Stoeger T, Beckers J, Wagner D, Singh I, Theis FJ, de Angelis MH, O'Connor T, Tacke F, Boutros M, Dejardin E, Eickelberg O, Schiller HB, Königshoff M, Heikenwalder M, Yildirim AÖ. Conlon TM, et al. Among authors: gosens r. Nature. 2020 Dec;588(7836):151-156. doi: 10.1038/s41586-020-2882-8. Epub 2020 Nov 4. Nature. 2020. PMID: 33149305 Free PMC article.
TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.
Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. Spanjer AI, et al. Among authors: gosens r. FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5. FASEB J. 2016. PMID: 26849959
Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for FZD8 in these responses.-Spanjer, A. I. R., Baarsma, H. A., Oostenbrink, L. M., Jansen, S. R., Kuipers, C. C., Lindner, M., P …
Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for …
WNT receptor signalling in lung physiology and pathology.
Skronska-Wasek W, Gosens R, Königshoff M, Baarsma HA. Skronska-Wasek W, et al. Among authors: gosens r. Pharmacol Ther. 2018 Jul;187:150-166. doi: 10.1016/j.pharmthera.2018.02.009. Epub 2018 Feb 17. Pharmacol Ther. 2018. PMID: 29458107 Review.
190 results