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EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR. Gorthi A, et al. Nature. 2018 Mar 15;555(7696):387-391. doi: 10.1038/nature25748. Epub 2018 Mar 7. Nature. 2018. PMID: 29513652 Free PMC article.
Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis.
Rajamanickam S, Panneerdoss S, Gorthi A, Timilsina S, Onyeagucha B, Kovalskyy D, Ivanov D, Hanes MA, Vadlamudi RK, Chen Y, Bishop AJ, Arbiser JL, Rao MK. Rajamanickam S, et al. Among authors: gorthi a. Clin Cancer Res. 2016 Jul 15;22(14):3524-36. doi: 10.1158/1078-0432.CCR-15-2535. Epub 2016 Feb 29. Clin Cancer Res. 2016. PMID: 26927663 Free PMC article.
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.
Zanotto-Filho A, Masamsetti VP, Loranc E, Tonapi SS, Gorthi A, Bernard X, Gonçalves RM, Moreira JC, Chen Y, Bishop AJ. Zanotto-Filho A, et al. Among authors: gorthi a. Mol Cancer Ther. 2016 Dec;15(12):3000-3014. doi: 10.1158/1535-7163.MCT-16-0271. Epub 2016 Sep 16. Mol Cancer Ther. 2016. PMID: 27638861 Free PMC article.
Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates.
Countryman P, Fan Y, Gorthi A, Pan H, Strickland E, Kaur P, Wang X, Lin J, Lei X, White C, You C, Wirth N, Tessmer I, Piehler J, Riehn R, Bishop AJR, Tao YJ, Wang H. Countryman P, et al. Among authors: gorthi a. J Biol Chem. 2018 Jan 19;293(3):1054-1069. doi: 10.1074/jbc.M117.806406. Epub 2017 Nov 24. J Biol Chem. 2018. PMID: 29175904 Free PMC article.
Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells.
Zanotto-Filho A, Rajamanickam S, Loranc E, Masamsetti VP, Gorthi A, Romero JC, Tonapi S, Gonçalves RM, Reddick RL, Benavides R, Kuhn J, Chen Y, Bishop AJR. Zanotto-Filho A, et al. Among authors: gorthi a. Cancer Lett. 2018 Jul 1;425:101-115. doi: 10.1016/j.canlet.2018.03.037. Epub 2018 Mar 30. Cancer Lett. 2018. PMID: 29608984 Free PMC article.
22 results