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In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K. Soukup O, et al. Among authors: gorecki l. Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657. Med Chem. 2018. PMID: 29332594
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.
Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L, Prchal L, Malinak D, Jun D, Musilek K, Worek F, Nachon F, Soukup O, Korabecny J. Gorecki L, et al. Arch Toxicol. 2021 Mar;95(3):985-1001. doi: 10.1007/s00204-021-02981-w. Epub 2021 Jan 31. Arch Toxicol. 2021. PMID: 33517499
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication.
Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K. Nepovimova E, et al. Among authors: gorecki l. Toxicol Res (Camb). 2016 May 25;5(4):1012-1016. doi: 10.1039/c6tx00130k. eCollection 2016 Jul 1. Toxicol Res (Camb). 2016. PMID: 30090408 Free PMC article.
Profiling donepezil template into multipotent hybrids with antioxidant properties.
Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D, Kuca K, Korabecny J. Mezeiova E, et al. Among authors: gorecki l. J Enzyme Inhib Med Chem. 2018 Dec;33(1):583-606. doi: 10.1080/14756366.2018.1443326. J Enzyme Inhib Med Chem. 2018. PMID: 29529892 Free PMC article. Review.
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators.
Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K. Malinak D, et al. Among authors: gorecki l. J Enzyme Inhib Med Chem. 2020 Dec;35(1):478-488. doi: 10.1080/14756366.2019.1710501. J Enzyme Inhib Med Chem. 2020. PMID: 31910701 Free PMC article.
33 results