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Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Huang YH, Chen CW, Sundaramurthy V, Słabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA. Huang YH, et al. Among authors: goodell ma. Cancer Discov. 2022 Jan;12(1):220-235. doi: 10.1158/2159-8290.CD-21-0560. Epub 2021 Aug 24. Cancer Discov. 2022. PMID: 34429321 Free PMC article.
Dnmt3a is essential for hematopoietic stem cell differentiation.
Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Challen GA, et al. Among authors: goodell ma. Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009. Nat Genet. 2011. PMID: 22138693 Free PMC article.
Large conserved domains of low DNA methylation maintained by Dnmt3a.
Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Jeong M, et al. Among authors: goodell ma. Nat Genet. 2014 Jan;46(1):17-23. doi: 10.1038/ng.2836. Epub 2013 Nov 24. Nat Genet. 2014. PMID: 24270360 Free PMC article.
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.
Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Challen GA, et al. Among authors: goodell ma. Cell Stem Cell. 2014 Sep 4;15(3):350-364. doi: 10.1016/j.stem.2014.06.018. Epub 2014 Aug 14. Cell Stem Cell. 2014. PMID: 25130491 Free PMC article.
DNMT3A in haematological malignancies.
Yang L, Rau R, Goodell MA. Yang L, et al. Among authors: goodell ma. Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19. Nat Rev Cancer. 2015. PMID: 25693834 Free PMC article. Review.
Long non-coding RNAs control hematopoietic stem cell function.
Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA. Luo M, et al. Among authors: goodell ma. Cell Stem Cell. 2015 Apr 2;16(4):426-38. doi: 10.1016/j.stem.2015.02.002. Epub 2015 Mar 12. Cell Stem Cell. 2015. PMID: 25772072 Free PMC article.
Acute loss of TET function results in aggressive myeloid cancer in mice.
An J, González-Avalos E, Chawla A, Jeong M, López-Moyado IF, Li W, Goodell MA, Chavez L, Ko M, Rao A. An J, et al. Among authors: goodell ma. Nat Commun. 2015 Nov 26;6:10071. doi: 10.1038/ncomms10071. Nat Commun. 2015. PMID: 26607761 Free PMC article.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. Yang L, et al. Among authors: goodell ma. Cancer Cell. 2016 Jun 13;29(6):922-934. doi: 10.1016/j.ccell.2016.05.003. Cancer Cell. 2016. PMID: 27300438 Free PMC article.
195 results