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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, Dwek RA, Schwartz P, Tong G, Wenger D, Lipton SA, Seyfried TN, Platt FM, Snyder EY. Lee JP, et al. Among authors: gonzalez r. Nat Med. 2007 Apr;13(4):439-47. doi: 10.1038/nm1548. Epub 2007 Mar 11. Nat Med. 2007. PMID: 17351625
Dorsomorphin promotes human embryonic stem cell self-renewal.
Gonzalez R, Lee JW, Snyder EY, Schultz PG. Gonzalez R, et al. Angew Chem Int Ed Engl. 2011 Apr 4;50(15):3439-41. doi: 10.1002/anie.201005659. Epub 2011 Mar 7. Angew Chem Int Ed Engl. 2011. PMID: 21384475 No abstract available.
Chemical mutagenesis of a GPCR ligand: Detoxifying "inflammo-attraction" to direct therapeutic stem cell migration.
Lee JP, Zhang R, Yan M, Duggineni S, Wakeman DR, Niles WL, Feng Y, Chen J, Hamblin MH, Han EB, Gonzalez R, Fang X, Zhu Y, Wang J, Xu Y, Wenger DA, Seyfried TN, An J, Sidman RL, Huang Z, Snyder EY. Lee JP, et al. Among authors: gonzalez r. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31177-31188. doi: 10.1073/pnas.1911444117. Epub 2020 Nov 20. Proc Natl Acad Sci U S A. 2020. PMID: 33219123 Free PMC article.
Neural Stem Cell Transplantation and CNS Diseases.
Gonzalez R, Hamblin MH, Lee JP. Gonzalez R, et al. CNS Neurol Disord Drug Targets. 2016;15(8):881-886. doi: 10.2174/1871527315666160815164247. CNS Neurol Disord Drug Targets. 2016. PMID: 27577573 Review.
Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease.
Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent LC, Elsworth JD, Sladek J, Snyder EY, Redmond DE Jr, Kern RA. Gonzalez R, et al. Cell Transplant. 2016 Nov;25(11):1945-1966. doi: 10.3727/096368916X691682. Cell Transplant. 2016. PMID: 27213850 Free article.
Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.
Redmond DE Jr, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR Jr, Sidman RL, Snyder EY. Redmond DE Jr, et al. Among authors: gonzalez r. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12175-80. doi: 10.1073/pnas.0704091104. Epub 2007 Jun 22. Proc Natl Acad Sci U S A. 2007. PMID: 17586681 Free PMC article.
Deriving dopaminergic neurons for clinical use. A practical approach.
Gonzalez R, Garitaonandia I, Abramihina T, Wambua GK, Ostrowska A, Brock M, Noskov A, Boscolo FS, Craw JS, Laurent LC, Snyder EY, Semechkin RA. Gonzalez R, et al. Sci Rep. 2013;3:1463. doi: 10.1038/srep01463. Sci Rep. 2013. PMID: 23492920 Free PMC article.
Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease.
Gonzalez R, Garitaonandia I, Crain A, Poustovoitov M, Abramihina T, Noskov A, Jiang C, Morey R, Laurent LC, Elsworth JD, Snyder EY, Redmond DE Jr, Semechkin R. Gonzalez R, et al. Cell Transplant. 2015;24(4):681-90. doi: 10.3727/096368915X687769. Epub 2015 Mar 24. Cell Transplant. 2015. PMID: 25839189 Free article.
4,672 results