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The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis.
Gonçalves-Oliveira LF, Souza-Silva F, de Castro Côrtes LM, Veloso LB, Santini Pereira BA, Cysne-Finkelstein L, Lechuga GC, Bourguignon SC, Almeida-Souza F, da Silva Calabrese K, Ferreira VF, Alves CR. Gonçalves-Oliveira LF, et al. Int J Parasitol Drugs Drug Resist. 2019 Aug;10:101-108. doi: 10.1016/j.ijpddr.2019.08.002. Epub 2019 Aug 12. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31430693 Free PMC article.
Impact of collaborative actions of Leishmania (Viannia) braziliensis subpopulations on the infection profile.
de Albuquerque-Melo BC, Cysne-Finkelstein L, Gonçalves-Oliveira LF, Cascabulho CM, Henriques-Pons A, Pereira MCS, Alves CR, Dias-Lopes G. de Albuquerque-Melo BC, et al. Among authors: goncalves oliveira lf. Parasitology. 2022 Oct;149(12):1526-1535. doi: 10.1017/S003118202200097X. Epub 2022 Jul 13. Parasitology. 2022. PMID: 35822537 Free PMC article.
Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2'-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites.
Peixoto JF, Oliveira ADS, Gonçalves-Oliveira LF, Souza-Silva F, Alves CR. Peixoto JF, et al. Among authors: goncalves oliveira lf. Braz J Infect Dis. 2023 Mar-Apr;27(2):102743. doi: 10.1016/j.bjid.2023.102743. Epub 2023 Jan 31. Braz J Infect Dis. 2023. PMID: 36731538 Free PMC article. Review.
Development of a microemulsion loaded with epoxy-α-lapachone against Leishmania (Leishmania) amazonensis murine infection.
Peixoto JF, Gonçalves-Oliveira LF, Souza-Silva F, Côrtes LMC, Dias-Lopes G, Cardoso FO, Santos RO, Patricio BFC, Nicoletti CD, Lima CGS, Calabrese KDS, Moreira DL, Rocha HVA, da Silva FC, Ferreira VF, Alves CR. Peixoto JF, et al. Among authors: goncalves oliveira lf. Int J Pharm. 2023 Apr 5;636:122864. doi: 10.1016/j.ijpharm.2023.122864. Epub 2023 Mar 17. Int J Pharm. 2023. PMID: 36934883
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis.
Peixoto JF, Gonçalves-Oliveira LF, Souza-Silva F, de Castro Côrtes LM, Finkelstein LC, Dias-Lopes G, Patricio BFC, Lima CGS, Rocha HVA, da Silva FC, Ferreira VF, Pereira BAS, Alves CR. Peixoto JF, et al. Among authors: goncalves oliveira lf. Int J Parasitol Drugs Drug Resist. 2024 Apr;24:100525. doi: 10.1016/j.ijpddr.2024.100525. Epub 2024 Feb 9. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38359731 Free PMC article.