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Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules.
Carloto ACM, Bortoleti BTDS, Rodrigues ACJ, Silva TF, Tomiotto-Pellissier F, Bidóia DL, Gonçalves MD, Assolini JP, Dekker RFH, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Carloto ACM, et al. Among authors: goncalves md. Chem Biol Interact. 2022 Jan 5;351:109713. doi: 10.1016/j.cbi.2021.109713. Epub 2021 Oct 23. Chem Biol Interact. 2022. PMID: 34699765
Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion: Leishmanicidal effect of Caryocar coriaceum leaf exracts.
Tomiotto-Pellissier F, Alves DR, Miranda-Sapla MM, de Morais SM, Assolini JP, da Silva Bortoleti BT, Gonçalves MD, Cataneo AHD, Kian D, Madeira TB, Yamauchi LM, Nixdorf SL, Costa IN, Conchon-Costa I, Pavanelli WR. Tomiotto-Pellissier F, et al. Among authors: goncalves md. Biomed Pharmacother. 2018 Feb;98:662-672. doi: 10.1016/j.biopha.2017.12.083. Epub 2018 Jan 4. Biomed Pharmacother. 2018. PMID: 29294453
Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis.
Gonçalves MD, Bortoleti BTS, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Carloto ACM, Carvalho PGC, Tudisco ET, Urbano A, Ambrósio SR, Hirooka EY, Simão ANC, Costa IN, Pavanelli WR, Conchon-Costa I, Arakawa NS. Gonçalves MD, et al. Fitoterapia. 2018 Jul;128:224-232. doi: 10.1016/j.fitote.2018.05.027. Epub 2018 May 23. Fitoterapia. 2018. PMID: 29802873
Grandiflorenic acid promotes death of promastigotes via apoptosis-like mechanism and affects amastigotes by increasing total iron bound capacity.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Miranda-Sapla MM, Assolini JP, Carloto ACM, de Carvalho PGC, Cardoso ILA, Simão ANC, Arakawa NS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Among authors: goncalves md. Phytomedicine. 2018 Jul 15;46:11-20. doi: 10.1016/j.phymed.2018.06.010. Epub 2018 Jun 13. Phytomedicine. 2018. PMID: 30097110
Macrophage Polarization in Leishmaniasis: Broadening Horizons.
Tomiotto-Pellissier F, Bortoleti BTDS, Assolini JP, Gonçalves MD, Carloto ACM, Miranda-Sapla MM, Conchon-Costa I, Bordignon J, Pavanelli WR. Tomiotto-Pellissier F, et al. Among authors: goncalves md. Front Immunol. 2018 Oct 31;9:2529. doi: 10.3389/fimmu.2018.02529. eCollection 2018. Front Immunol. 2018. PMID: 30429856 Free PMC article. Review.
Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability.
Bortoleti BTDS, Tomiotto-Pellissier F, Gonçalves MD, Miranda-Sapla MM, Assolini JP, Carloto AC, Lima DM, Silveira GF, Almeida RS, Costa IN, Conchon-Costa I, Pavanelli WR. Bortoleti BTDS, et al. Among authors: goncalves md. Phytomedicine. 2019 Apr;57:262-270. doi: 10.1016/j.phymed.2018.12.035. Epub 2018 Dec 31. Phytomedicine. 2019. PMID: 30802712
trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability.
Miranda-Sapla MM, Tomiotto-Pellissier F, Assolini JP, Carloto ACM, Bortoleti BTDS, Gonçalves MD, Tavares ER, Rodrigues JHDS, Simão ANC, Yamauchi LM, Nakamura CV, Verri WA Jr, Costa IN, Conchon-Costa I, Pavanelli WR. Miranda-Sapla MM, et al. Among authors: goncalves md. Eur J Pharmacol. 2019 Jun 15;853:275-288. doi: 10.1016/j.ejphar.2019.03.049. Epub 2019 Apr 6. Eur J Pharmacol. 2019. PMID: 30965057
Reactivation of Cytomegalovirus Increases Nitric Oxide and IL-10 Levels in Sepsis and is Associated with Changes in Renal Parameters and Worse Clinical Outcome.
Silva TF, Concato VM, Tomiotto-Pellissier F, Gonçalves MD, Bortoleti BTDS, Tavares ER, Yamauchi LM, Grion CMC, Simão ANC, Miranda-Sapla MM, Costa IN, Pavanelli WR, Conchon-Costa I. Silva TF, et al. Among authors: goncalves md. Sci Rep. 2019 Jun 21;9(1):9016. doi: 10.1038/s41598-019-45390-x. Sci Rep. 2019. PMID: 31227794 Free PMC article.
3,3',5,5'-tetramethoxybiphenyl-4,4'diol induces cell cycle arrest in G2/M phase and apoptosis in human non-small cell lung cancer A549 cells.
Concato VM, Tomiotto-Pellissier F, Silva TF, Gonçalves MD, Bortoleti BTDS, Detoni MB, Siqueira EDS, Rodrigues ACJ, Schirmann JG, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Mantovani MS, Pavanelli WR. Concato VM, et al. Among authors: goncalves md. Chem Biol Interact. 2020 Aug 1;326:109133. doi: 10.1016/j.cbi.2020.109133. Epub 2020 May 24. Chem Biol Interact. 2020. PMID: 32461103
138 results