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Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-γ signalling.
Cao LL, Lu H, Soutto M, Bhat N, Chen Z, Peng D, Gomaa A, Wang JB, Xie JW, Li P, Zheng CH, Nomura S, Datta J, Merchant N, Chen ZB, Villarino A, Zaika A, Huang CM, El-Rifai W. Cao LL, et al. Among authors: gomaa a. Gut. 2023 Nov;72(11):2038-2050. doi: 10.1136/gutjnl-2022-329134. Epub 2023 Jul 4. Gut. 2023. PMID: 37402563
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Soutto M, Chen Z, Bhat AA, Wang L, Zhu S, Gomaa A, Bates A, Bhat NS, Peng D, Belkhiri A, Piazuelo MB, Washington MK, Steven XC, Peek R Jr, El-Rifai W. Soutto M, et al. Among authors: gomaa a. Nat Commun. 2019 Jul 10;10(1):3039. doi: 10.1038/s41467-019-11011-4. Nat Commun. 2019. PMID: 31292446 Free PMC article.
Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.
Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W. Wang-Bishop L, et al. Among authors: gomaa a. Gastroenterology. 2019 Feb;156(3):662-675.e7. doi: 10.1053/j.gastro.2018.10.030. Epub 2018 Oct 17. Gastroenterology. 2019. PMID: 30342037 Free PMC article.
301 results