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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Venegas C, et al. Among authors: golenbock dt. Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158. Nature. 2017. PMID: 29293211
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. Heneka MT, et al. Among authors: golenbock dt. Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19. Nature. 2013. PMID: 23254930 Free PMC article.
Innate immunity in Alzheimer's disease.
Heneka MT, Golenbock DT, Latz E. Heneka MT, et al. Among authors: golenbock dt. Nat Immunol. 2015 Mar;16(3):229-36. doi: 10.1038/ni.3102. Nat Immunol. 2015. PMID: 25689443 Review.
NLRP3 inflammasome activation drives tau pathology.
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT. Ising C, et al. Among authors: golenbock dt. Nature. 2019 Nov;575(7784):669-673. doi: 10.1038/s41586-019-1769-z. Epub 2019 Nov 20. Nature. 2019. PMID: 31748742 Free PMC article.
Neuroinflammation in Alzheimer's disease.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Heneka MT, et al. Among authors: golenbock dt. Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Lancet Neurol. 2015. PMID: 25792098 Free PMC article. Review.
Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT. Scheiblich H, et al. Among authors: golenbock dt. J Neurochem. 2017 Dec;143(5):534-550. doi: 10.1111/jnc.14225. Epub 2017 Oct 26. J Neurochem. 2017. PMID: 28940479 Free article.
Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT. Tzeng TC, et al. Among authors: golenbock dt. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9002-9007. doi: 10.1073/pnas.1801802115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127003 Free PMC article.
256 results