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NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation.
Goess C, Terrillon S, Mayo M, Bousquet P, Wallace C, Hart M, Mathieu S, Twomey R, Donnelly-Roberts D, Namovic M, Jung P, Hu M, Richardson P, Esbenshade T, Cuff CA. Goess C, et al. J Transl Autoimmun. 2020 Dec 23;4:100079. doi: 10.1016/j.jtauto.2020.100079. eCollection 2021. J Transl Autoimmun. 2020. PMID: 33490940 Free PMC article.
Inhibition of Interleukin-23-Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt.
Gauld SB, Jacquet S, Gauvin D, Wallace C, Wang Y, McCarthy R, Goess C, Leys L, Huang S, Su Z, Edelmayer R, Wetter J, Salte K, McGaraughty SP, Argiriadi MA, Honore P, Luccarini JM, Bressac D, Desino K, Breinlinger E, Cusack K, Potin D, Kort ME, Masson PJ. Gauld SB, et al. Among authors: goess c. J Pharmacol Exp Ther. 2019 Oct;371(1):208-218. doi: 10.1124/jpet.119.258046. Epub 2019 Aug 2. J Pharmacol Exp Ther. 2019. PMID: 31375639
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Dietrich JD, Longenecker KL, Wilson NS, Goess C, Panchal SC, Swann SL, Petros AM, Hobson AD, Ihle D, Song D, Richardson P, Comess KM, Cox PB, Dombrowski A, Sarris K, Donnelly-Roberts DL, Duignan DB, Gomtsyan A, Jung P, Krueger AC, Mathieu S, McClure A, Stoll VS, Wetter J, Mankovich JA, Hajduk PJ, Vasudevan A, Stoffel RH, Sun C. Dietrich JD, et al. Among authors: goess c. J Med Chem. 2021 Jan 14;64(1):417-429. doi: 10.1021/acs.jmedchem.0c01280. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33378180
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads.
Hobson AD, McPherson MJ, Waegell W, Goess CA, Stoffel RH, Li X, Zhou J, Wang Z, Yu Y, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Pawlikowska M, Puthenveetil S, Santora LC, Wang L, Wang L, Marvin CC, Hayes ME, Shrestha A, Sarris KA, Li B. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2022 Mar 24;65(6):4500-4533. doi: 10.1021/acs.jmedchem.1c02099. Epub 2022 Feb 8. J Med Chem. 2022. PMID: 35133822
Optimization of Drug-Linker to Enable Long-term Storage of Antibody-Drug Conjugate for Subcutaneous Dosing.
Hobson AD, Xu J, Marvin CC, McPherson MJ, Hollmann M, Gattner M, Dzeyk K, Fettis MM, Bischoff AK, Wang L, Fitzgibbons J, Wang L, Salomon P, Hernandez A Jr, Jia Y, Sarvaiya H, Goess CA, Mathieu SL, Santora LC. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2023 Jul 13;66(13):9161-9173. doi: 10.1021/acs.jmedchem.3c00794. Epub 2023 Jun 28. J Med Chem. 2023. PMID: 37379257
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC).
Hobson AD, Xu J, Welch DS, Marvin CC, McPherson MJ, Gates B, Liao X, Hollmann M, Gattner MJ, Dzeyk K, Sarvaiya H, Shenoy VM, Fettis MM, Bischoff AK, Wang L, Santora LC, Wang L, Fitzgibbons J, Salomon P, Hernandez A Jr, Jia Y, Goess CA, Mathieu SL, Bryant SH, Larsen ME, Cui B, Tian Y. Hobson AD, et al. Among authors: goess ca. J Med Chem. 2023 Sep 14;66(17):12544-12558. doi: 10.1021/acs.jmedchem.3c01174. Epub 2023 Sep 1. J Med Chem. 2023. PMID: 37656698
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.
Hobson AD, McPherson MJ, Hayes ME, Goess C, Li X, Zhou J, Wang Z, Yu Y, Yang J, Sun L, Zhang Q, Qu P, Yang S, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Santora LC, Wang L, Wang L, Fettis MM, Li X, Marvin CC, Wang Z, Patel MV, Schmidt DL, Li T, Randolph JT, Henry RF, Graff C, Tian Y, Aguirre AL, Shrestha A. Hobson AD, et al. Among authors: goess c. J Med Chem. 2022 Dec 8;65(23):15893-15934. doi: 10.1021/acs.jmedchem.2c01579. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36394224
27 results