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MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells.
Vimonpatranon S, Goes LR, Chan A, Licavoli I, McMurry J, Wertz SR, Arakelyan A, Huang D, Jiang A, Huang C, Zhou J, Yolitz J, Girard A, Van Ryk D, Wei D, Hwang IY, Martens C, Kanakabandi K, Virtaneva K, Ricklefs S, Darwitz BP, Soares MA, Pattanapanyasat K, Fauci AS, Arthos J, Cicala C. Vimonpatranon S, et al. Among authors: goes lr. PLoS Pathog. 2023 Mar 10;19(3):e1011209. doi: 10.1371/journal.ppat.1011209. eCollection 2023 Mar. PLoS Pathog. 2023. PMID: 36897929 Free PMC article.
MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.
Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J. Nawaz F, et al. Among authors: goes lr. Mucosal Immunol. 2018 Sep;11(5):1342-1351. doi: 10.1038/s41385-018-0044-1. Epub 2018 Jun 6. Mucosal Immunol. 2018. PMID: 29875402 Free PMC article.
The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection.
Goes LR, Sajani A, Sivro A, Olowojesiku R, Ray JC, Perrone I, Yolitz J, Girard A, Leyre L, Wibmer CK, Morris L, Gorini G, Franchini G, Mason RD, Roederer M, Mehandru S, Soares MA, Cicala C, Fauci AS, Arthos J. Goes LR, et al. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32566-32573. doi: 10.1073/pnas.2011501117. Epub 2020 Dec 7. Proc Natl Acad Sci U S A. 2020. PMID: 33288704 Free PMC article.
16 results