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Page 1
Desmopressin testing in von Willebrand disease: Lowering the burden.
Res Pract Thromb Haemost. 2022 Sep 26;6(6):e12784. doi: 10.1002/rth2.12784. eCollection 2022 Aug.
Res Pract Thromb Haemost. 2022.
PMID: 36186107
Free PMC article.
Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study.
Heijdra JM, Al Arashi W, de Jager NCB, Cloesmeijer ME, Bukkems LH, Zwaan CM, Leebeek FWG, Mathôt RAA, Cnossen MH; OPTI-CLOT Study Group.
Heijdra JM, et al.
BMJ Open. 2022 Feb 15;12(2):e049493. doi: 10.1136/bmjopen-2021-049493.
BMJ Open. 2022.
PMID: 35168962
Free PMC article.
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A Generative and Causal Pharmacokinetic Model for Factor VIII in Hemophilia A: A Machine Learning Framework for Continuous Model Refinement.
Janssen A, Smalbil L, Bennis FC, Cnossen MH, Mathôt RAA; OPTI-CLOT study group and SYMPHONY consortium.
Janssen A, et al.
Clin Pharmacol Ther. 2024 Apr;115(4):881-889. doi: 10.1002/cpt.3203. Epub 2024 Feb 19.
Clin Pharmacol Ther. 2024.
PMID: 38372445
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One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P® /Humate P® treatment in von Willebrand disease patients.
de Jager NCB, Bukkems LH, Heijdra JM, Hazendonk CHCAM, Fijnvandraat K, Meijer K, Eikenboom J, Laros-van Gorkom BAP, Leebeek FWG, Cnossen MH, Mathôt RAA; OPTI-CLOT group.
de Jager NCB, et al.
J Thromb Haemost. 2020 Feb;18(2):295-305. doi: 10.1111/jth.14652. Epub 2019 Oct 21.
J Thromb Haemost. 2020.
PMID: 31557387
Free PMC article.
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Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial.
van Moort I, Preijers T, Bukkems LH, Hazendonk HCAM, van der Bom JG, Laros-van Gorkom BAP, Beckers EAM, Nieuwenhuizen L, van der Meer FJM, Ypma P, Coppens M, Fijnvandraat K, Schutgens REG, Meijer K, Leebeek FWG, Mathôt RAA, Cnossen MH; OPTI-CLOT study group.
van Moort I, et al.
Lancet Haematol. 2021 Jul;8(7):e492-e502. doi: 10.1016/S2352-3026(21)00135-6.
Lancet Haematol. 2021.
PMID: 34171280
Clinical Trial.
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