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Page 1
Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice.
Holland CH, Ramirez Flores RO, Myllys M, Hassan R, Edlund K, Hofmann U, Marchan R, Cadenas C, Reinders J, Hoehme S, Seddek AL, Dooley S, Keitel V, Godoy P, Begher-Tibbe B, Trautwein C, Rupp C, Mueller S, Longerich T, Hengstler JG, Saez-Rodriguez J, Ghallab A. Holland CH, et al. Among authors: godoy p. Hepatol Commun. 2022 Jan;6(1):161-177. doi: 10.1002/hep4.1797. Epub 2021 Aug 28. Hepatol Commun. 2022. PMID: 34558834 Free PMC article.
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.
Ghallab A, Cellière G, Henkel SG, Driesch D, Hoehme S, Hofmann U, Zellmer S, Godoy P, Sachinidis A, Blaszkewicz M, Reif R, Marchan R, Kuepfer L, Häussinger D, Drasdo D, Gebhardt R, Hengstler JG. Ghallab A, et al. Among authors: godoy p. J Hepatol. 2016 Apr;64(4):860-71. doi: 10.1016/j.jhep.2015.11.018. Epub 2015 Nov 27. J Hepatol. 2016. PMID: 26639393 Free article.
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.
Campos G, Schmidt-Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas DB, Hetz C, Widera A, Cadenas C, Begher-Tibbe B, Reif R, Günther G, Sachinidis A, Hengstler JG, Godoy P. Campos G, et al. Among authors: godoy p. Arch Toxicol. 2014 Jun;88(6):1267-80. doi: 10.1007/s00204-014-1240-8. Epub 2014 Apr 20. Arch Toxicol. 2014. PMID: 24748426
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.
Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG. Godoy P, et al. J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25. J Hepatol. 2015. PMID: 26022688 Free PMC article.
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG. Godoy P, et al. Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23. Arch Toxicol. 2016. PMID: 27339419 Free PMC article.
Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.
Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R. Ghallab A, et al. Among authors: godoy p. Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19. Hepatology. 2019. PMID: 30102412 Free PMC article.
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG. Grinberg M, et al. Among authors: godoy p. Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3. Arch Toxicol. 2018. PMID: 30511339
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Campos G, Schmidt-Heck W, De Smedt J, Widera A, Ghallab A, Pütter L, González D, Edlund K, Cadenas C, Marchan R, Guthke R, Verfaillie C, Hetz C, Sachinidis A, Braeuning A, Schwarz M, Weiß TS, Banhart BK, Hoek J, Vadigepalli R, Willy J, Stevens JL, Hay DC, Hengstler JG, Godoy P. Campos G, et al. Among authors: godoy p. Arch Toxicol. 2020 Jan;94(1):205-217. doi: 10.1007/s00204-019-02630-3. Epub 2020 Jan 9. Arch Toxicol. 2020. PMID: 31919559
Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria.
Gianmoena K, Gasparoni N, Jashari A, Gabrys P, Grgas K, Ghallab A, Nordström K, Gasparoni G, Reinders J, Edlund K, Godoy P, Schriewer A, Hayen H, Hudert CA, Damm G, Seehofer D, Weiss TS, Boor P, Anders HJ, Motrapu M, Jansen P, Schiergens TS, Falk-Paulsen M, Rosenstiel P, Lisowski C, Salido E, Marchan R, Walter J, Hengstler JG, Cadenas C. Gianmoena K, et al. Among authors: godoy p. Cell Rep. 2021 Aug 24;36(8):109526. doi: 10.1016/j.celrep.2021.109526. Cell Rep. 2021. PMID: 34433051 Free article.
524 results