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Showing results for goiania yl
Search for Godhania YL instead (1 results)
3-Benzoyl-1-[4-(methyl-sulfan-yl)phen-yl]thio-urea.
Castro Rde P, Macedo FC Jr, Brito TO, de Fátima A, Sabino JR. Castro Rde P, et al. Acta Crystallogr Sect E Struct Rep Online. 2013 May 18;69(Pt 6):o923. doi: 10.1107/S1600536813013159. Print 2013 Jun 1. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 23795092 Free PMC article.
An intra-molecular N-HO hydrogen bond leads to a six-membered pseudo-ring [r.m.s. deviation = 0.0212 A, maximum deviation = 0.033 (1) A for the N atom bearing the benzoyl group] in the central unit. The benzene and (methyl-sulfan-yl)benzene ring [r.m.s = 0.0028 A and large …
An intra-molecular N-HO hydrogen bond leads to a six-membered pseudo-ring [r.m.s. deviation = 0.0212 A, maximum deviation = 0.033 (1) A for …
rac-5-(1-Methyl-eth-yl)-2-sulfanylidene-imidazolidin-4-one.
Castro Rde P, Macedo FC Jr, Brito TO, de Fátima A, Sabino JR. Castro Rde P, et al. Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 5;69(Pt 5):o643. doi: 10.1107/S1600536813008337. Print 2013 May 1. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 23723808 Free PMC article.
Neuropharmacological Activity of the New Piperazine Derivative 2-(4-((1- Phenyl-1H-Pyrazol-4-yl)Methyl)Piperazin-1-yl)Ethyl Acetate is Modulated by Serotonergic and GABAergic Pathways.
Almeida LS, Santana IGC, da Silva Moreira LK, Turones LC, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Menegatti R, Costa EA, de Brito AF. Almeida LS, et al. CNS Neurol Disord Drug Targets. 2022;21(6):520-532. doi: 10.2174/1871527320666211112173233. CNS Neurol Disord Drug Targets. 2022. PMID: 34781873
OBJECTIVES: In this study, we proposed the design, synthesis of a new compound, 2-(4-((1- phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethyl acetate (LQFM192), pharmacological evaluation of its anxiolytic-like and antidepressant-like activities, as well as the possi …
OBJECTIVES: In this study, we proposed the design, synthesis of a new compound, 2-(4-((1- phenyl-1H-pyrazol-4-yl)methyl)piperazin-1- …
Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
Menegatti R, Carvalho FS, Lião LM, Villavicencio B, Verli H, Mourão AA, Xavier CH, Castro CH, Pedrino GR, Franco OL, Oliveira-Silva I, Ashpole NM, Silva ON, Costa EA, Fajemiroye JO. Menegatti R, et al. Naunyn Schmiedebergs Arch Pharmacol. 2019 Sep;392(9):1071-1083. doi: 10.1007/s00210-019-01649-8. Epub 2019 May 2. Naunyn Schmiedebergs Arch Pharmacol. 2019. PMID: 31049606
The current study investigates the effects of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol (LQFM032) on cardiovascular function and cholinergic-nitric oxide signaling. ...
The current study investigates the effects of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol (LQFM032) on ca …
Anxiolytic-like effect of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathways.
Brito AF, Fajemiroye JO, Neri HFS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Ghedini PC, Lião LM, Menegatti R, Costa EA. Brito AF, et al. Chem Biol Drug Des. 2017 Sep;90(3):432-442. doi: 10.1111/cbdd.12961. Epub 2017 Mar 6. Chem Biol Drug Des. 2017. PMID: 28160425
In this study, we proposed the design, synthesis of a new compound 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol (LQFM032), and pharmacological evaluation of its anxiolytic-like effect. ...
In this study, we proposed the design, synthesis of a new compound 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan …
KIO4 -mediated Selective Hydroxymethylation/Methylenation of Imidazo-Heteroarenes: A Greener Approach.
Franco MS, Saba S, Rafique J, Braga AL. Franco MS, et al. Angew Chem Int Ed Engl. 2021 Aug 16;60(34):18454-18460. doi: 10.1002/anie.202104503. Epub 2021 Jul 16. Angew Chem Int Ed Engl. 2021. PMID: 34097781
., Zolpidem. Furthermore, by using glycerol, bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives were selectively obtained in good to excellent yields....
., Zolpidem. Furthermore, by using glycerol, bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives were selectively obtained in good to …
Absolute configuration of strictosidinic acid.
Castro Rde P, Matos Cda S, do Nascimento CA, Oliveira CM, Kato L, Lião LM, Sabino JR. Castro Rde P, et al. Acta Crystallogr C. 2012 Apr;68(Pt 4):m94-6. doi: 10.1107/S0108270112010372. Epub 2012 Mar 14. Acta Crystallogr C. 2012. PMID: 22476143
The absolute configuration of strictosidinic acid, (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-4-{[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl}-3,4-dihydro-2H-pyran-5-carboxylate, was determined from its sodium chloride trihydrate, poly[[diaqua((2S,3R,4 …
The absolute configuration of strictosidinic acid, (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-4-{[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3 …
New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities.
de Oliveira LP, da Silva DP, Florentino IF, Fajemiroye JO, de Oliveira TS, Marcelino RI, Pazini F, Lião LM, Ghedini PC, de Moura SS, Valadares MC, de Carvalho VV, Vaz BG, Menegatti R, Costa EA. de Oliveira LP, et al. Chem Biol Drug Des. 2017 Jan;89(1):124-135. doi: 10.1111/cbdd.12838. Epub 2016 Sep 14. Chem Biol Drug Des. 2017. PMID: 27526659
In response to pyrazole compounds' antipyretic, analgesic, and anti-inflammatory effects, this study sought to evaluate the analgesic, anti-inflammatory, and vasorelaxant effects, as well as the mechanisms of action, of a new pyrazole derivative, 5-[1-(4-fluorophenyl)-1H-pyrazol- …
In response to pyrazole compounds' antipyretic, analgesic, and anti-inflammatory effects, this study sought to evaluate the analgesic, anti- …
A new piperazine derivative: 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one with antioxidant and central activity.
Brito AF, Braga PCCS, Moreira LKS, Silva DM, Silva DPB, Sanz G, Vaz BG, de Carvalho FS, Lião LM, Silva RR, Noël F, Neri HFS, Ghedini PC, de Carvalho MF, de S Gil E, Costa EA, Menegatti R. Brito AF, et al. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):255-269. doi: 10.1007/s00210-017-1451-7. Epub 2017 Dec 19. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29260264
In the scope of a research program aimed at developing new drugs for the treatment of central nervous system diseases, we describe herein the synthesis and pharmacological evaluation of 1-(4-(3,5-di-tert-butyl-4-hydroxybenzyl) piperazin-1-yl)-2-methoxyethan-1-one (LQFM180) …
In the scope of a research program aimed at developing new drugs for the treatment of central nervous system diseases, we describe herein th …
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