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Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology.
Alzheimers Res Ther. 2020 Nov 14;12(1):149. doi: 10.1186/s13195-020-00719-x.
Alzheimers Res Ther. 2020.
PMID: 33189132
Free PMC article.
Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy.
Piechotta A, Parthier C, Kleinschmidt M, Gnoth K, Pillot T, Lues I, Demuth HU, Schilling S, Rahfeld JU, Stubbs MT.
Piechotta A, et al. Among authors: gnoth k.
J Biol Chem. 2017 Jul 28;292(30):12713-12724. doi: 10.1074/jbc.M117.777839. Epub 2017 Jun 16.
J Biol Chem. 2017.
PMID: 28623233
Free PMC article.
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Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice.
Gnoth K, Geissler S, Feldhaus J, Taudte N, Ilse V, Zürner S, Greiser S, Braumann UD, Rahfeld JU, Cynis H, Schilling S.
Gnoth K, et al.
Biomolecules. 2022 Mar 4;12(3):399. doi: 10.3390/biom12030399.
Biomolecules. 2022.
PMID: 35327591
Free PMC article.
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Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer's disease.
Li X, Ospitalieri S, Robberechts T, Hofmann L, Schmid C, Rijal Upadhaya A, Koper MJ, von Arnim CAF, Kumar S, Willem M, Gnoth K, Ramakers M, Schymkowitz J, Rousseau F, Walter J, Ronisz A, Balakrishnan K, Thal DR.
Li X, et al. Among authors: gnoth k.
Brain. 2022 Oct 21;145(10):3558-3570. doi: 10.1093/brain/awac202.
Brain. 2022.
PMID: 36270003
Free PMC article.
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Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme.
Gnoth K, Bär JW, Rosche F, Rahfeld JU, Demuth HU.
Gnoth K, et al.
PLoS One. 2024 Apr 16;19(4):e0289239. doi: 10.1371/journal.pone.0289239. eCollection 2024.
PLoS One. 2024.
PMID: 38625918
Free PMC article.
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