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Ubiquitin-independent proteasomal degradation driven by C-degron pathways.
Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I. Makaros Y, et al. Among authors: glickman mh. Mol Cell. 2023 Jun 1;83(11):1921-1935.e7. doi: 10.1016/j.molcel.2023.04.023. Epub 2023 May 17. Mol Cell. 2023. PMID: 37201526 Free PMC article.
Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model.
Maniv I, Sarji M, Bdarneh A, Feldman A, Ankawa R, Koren E, Magid-Gold I, Reis N, Soteriou D, Salomon-Zimri S, Lavy T, Kesselman E, Koifman N, Kurz T, Kleifeld O, Michaelson D, van Leeuwen FW, Verheijen BM, Fuchs Y, Glickman MH. Maniv I, et al. Among authors: glickman mh. Nat Commun. 2023 Sep 22;14(1):5922. doi: 10.1038/s41467-023-41545-7. Nat Commun. 2023. PMID: 37739965 Free PMC article.
A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing.
Sahu I, Bajorek M, Tan X, Srividya M, Krutauz D, Reis N, Osmulski PA, Gaczynska ME, Glickman MH. Sahu I, et al. Among authors: glickman mh. Biomolecules. 2023 Mar 5;13(3):480. doi: 10.3390/biom13030480. Biomolecules. 2023. PMID: 36979414 Free PMC article.
The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag.
Sahu I, Mali SM, Sulkshane P, Xu C, Rozenberg A, Morag R, Sahoo MP, Singh SK, Ding Z, Wang Y, Day S, Cong Y, Kleifeld O, Brik A, Glickman MH. Sahu I, et al. Among authors: glickman mh. Nat Commun. 2021 Oct 26;12(1):6173. doi: 10.1038/s41467-021-26427-0. Nat Commun. 2021. PMID: 34702852 Free PMC article.
124 results