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Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2.
Indrigo M, Morella I, Orellana D, d'Isa R, Papale A, Parra R, Gurgone A, Lecca D, Cavaccini A, Tigaret CM, Cagnotto A, Jones K, Brooks S, Ratto GM, Allen ND, Lelos MJ, Middei S, Giustetto M, Carta AR, Tonini R, Salmona M, Hall J, Thomas K, Brambilla R, Fasano S. Indrigo M, et al. Among authors: giustetto m. EMBO Mol Med. 2023 Nov 8;15(11):e15984. doi: 10.15252/emmm.202215984. Epub 2023 Oct 4. EMBO Mol Med. 2023. PMID: 37792911 Free PMC article.
Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.
Fasano S, D'Antoni A, Orban PC, Valjent E, Putignano E, Vara H, Pizzorusso T, Giustetto M, Yoon B, Soloway P, Maldonado R, Caboche J, Brambilla R. Fasano S, et al. Among authors: giustetto m. Biol Psychiatry. 2009 Oct 15;66(8):758-68. doi: 10.1016/j.biopsych.2009.03.014. Epub 2009 May 15. Biol Psychiatry. 2009. PMID: 19446794 Free PMC article.
mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder.
Gurgone A, Pizzo R, Raspanti A, Chiantia G, Devi S, Comai D, Morello N, Pilotto F, Gnavi S, Lupori L, Mazziotti R, Sagona G, Putignano E, Nocentini A, Supuran CT, Marcantoni A, Pizzorusso T, Giustetto M. Gurgone A, et al. Among authors: giustetto m. Neuropsychopharmacology. 2023 May;48(6):877-886. doi: 10.1038/s41386-022-01412-3. Epub 2022 Aug 9. Neuropsychopharmacology. 2023. PMID: 35945276 Free PMC article.
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.
Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C. Vicidomini C, et al. Among authors: giustetto m. Mol Psychiatry. 2017 May;22(5):689-702. doi: 10.1038/mp.2016.30. Epub 2016 Mar 29. Mol Psychiatry. 2017. PMID: 27021819 Free PMC article.
Homer1b/c clustering is impaired in Phelan-McDermid Syndrome iPSCs derived neurons.
Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C. Vicidomini C, et al. Among authors: giustetto m. Mol Psychiatry. 2017 May;22(5):637. doi: 10.1038/mp.2017.82. Mol Psychiatry. 2017. PMID: 28428614 No abstract available.
Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death.
Gennaccaro L, Fuchs C, Loi M, Pizzo R, Alvente S, Berteotti C, Lupori L, Sagona G, Galvani G, Gurgone A, Raspanti A, Medici G, Tassinari M, Trazzi S, Ren E, Rimondini R, Pizzorusso T, Zoccoli G, Giustetto M, Ciani E. Gennaccaro L, et al. Among authors: giustetto m. Aging Dis. 2021 Jun 1;12(3):764-785. doi: 10.14336/AD.2020.0827. eCollection 2021 Jun. Aging Dis. 2021. PMID: 34094641 Free PMC article.
63 results