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Genome-wide off-targets of drugs: risks and opportunities.
Giri AK, Ianevski A, Aittokallio T. Giri AK, et al. Cell Biol Toxicol. 2019 Dec;35(6):485-487. doi: 10.1007/s10565-019-09491-7. Epub 2019 Aug 20. Cell Biol Toxicol. 2019. PMID: 31432301 No abstract available.
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations.
Ianevski A, Lahtela J, Javarappa KK, Sergeev P, Ghimire BR, Gautam P, Vähä-Koskela M, Turunen L, Linnavirta N, Kuusanmäki H, Kontro M, Porkka K, Heckman CA, Mattila P, Wennerberg K, Giri AK, Aittokallio T. Ianevski A, et al. Among authors: giri ak. Sci Adv. 2021 Feb 19;7(8):eabe4038. doi: 10.1126/sciadv.abe4038. Print 2021 Feb. Sci Adv. 2021. PMID: 33608276 Free PMC article.
Prediction of drug combination effects with a minimal set of experiments.
Ianevski A, Giri AK, Gautam P, Kononov A, Potdar S, Saarela J, Wennerberg K, Aittokallio T. Ianevski A, et al. Among authors: giri ak. Nat Mach Intell. 2019 Dec;1(12):568-577. doi: 10.1038/s42256-019-0122-4. Epub 2019 Dec 9. Nat Mach Intell. 2019. PMID: 32368721 Free PMC article.
JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.
Wahnschaffe L, Braun T, Timonen S, Giri AK, Schrader A, Wagle P, Almusa H, Johansson P, Bellanger D, López C, Haferlach C, Stern MH, Dürig J, Siebert R, Mustjoki S, Aittokallio T, Herling M. Wahnschaffe L, et al. Among authors: giri ak. Cancers (Basel). 2019 Nov 21;11(12):1833. doi: 10.3390/cancers11121833. Cancers (Basel). 2019. PMID: 31766351 Free PMC article.
Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine.
Pützer S, Varghese L, von Jan J, Braun T, Giri AK, Mayer P, Riet N, Timonen S, Oberbeck S, Kuusanmäki H, Mustjoki S, Stern MH, Aittokallio T, Newrzela S, Schrader A, Herling M. Pützer S, et al. Among authors: giri ak. Leukemia. 2020 Sep;34(9):2513-2518. doi: 10.1038/s41375-020-0772-6. Epub 2020 Feb 25. Leukemia. 2020. PMID: 32099034 Free article. No abstract available.
209 results