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6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.
Cilibrizzi A, Quinn MT, Kirpotina LN, Schepetkin IA, Holderness J, Ye RD, Rabiet MJ, Biancalani C, Cesari N, Graziano A, Vergelli C, Pieretti S, Dal Piaz V, Giovannoni MP. Cilibrizzi A, et al. Among authors: giovannoni mp. J Med Chem. 2009 Aug 27;52(16):5044-57. doi: 10.1021/jm900592h. J Med Chem. 2009. PMID: 19639995 Free PMC article.
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.
Biancalani C, Giovannoni MP, Pieretti S, Cesari N, Graziano A, Vergelli C, Cilibrizzi A, Di Gianuario A, Colucci M, Mangano G, Garrone B, Polenzani L, Dal Piaz V. Biancalani C, et al. Among authors: giovannoni mp. J Med Chem. 2009 Dec 10;52(23):7397-409. doi: 10.1021/jm900458r. J Med Chem. 2009. PMID: 19788200
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.
Biagini P, Biancalani C, Graziano A, Cesari N, Giovannoni MP, Cilibrizzi A, Dal Piaz V, Vergelli C, Crocetti L, Delcanale M, Armani E, Rizzi A, Puccini P, Gallo PM, Spinabelli D, Caruso P. Biagini P, et al. Among authors: giovannoni mp. Bioorg Med Chem. 2010 May 15;18(10):3506-17. doi: 10.1016/j.bmc.2010.03.066. Epub 2010 Mar 31. Bioorg Med Chem. 2010. PMID: 20413313
PDE5 inhibitors and their applications.
Giovannoni MP, Vergelli C, Graziano A, Dal Piaz V. Giovannoni MP, et al. Curr Med Chem. 2010;17(24):2564-87. doi: 10.2174/092986710791859360. Curr Med Chem. 2010. PMID: 20491634 Review.
Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.
Cilibrizzi A, Schepetkin IA, Bartolucci G, Crocetti L, Dal Piaz V, Giovannoni MP, Graziano A, Kirpotina LN, Quinn MT, Vergelli C. Cilibrizzi A, et al. Among authors: giovannoni mp. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92. doi: 10.1016/j.bmc.2012.04.043. Epub 2012 Apr 27. Bioorg Med Chem. 2012. PMID: 22607879 Free PMC article.
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.
Giovannoni MP, Schepetkin IA, Cilibrizzi A, Crocetti L, Khlebnikov AI, Dahlgren C, Graziano A, Dal Piaz V, Kirpotina LN, Zerbinati S, Vergelli C, Quinn MT. Giovannoni MP, et al. Eur J Med Chem. 2013 Jun;64:512-28. doi: 10.1016/j.ejmech.2013.03.066. Epub 2013 Apr 8. Eur J Med Chem. 2013. PMID: 23685570 Free PMC article.
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